Differential diagnosis and treatment of infectious cutaneous granuloma caused by Actinomyces and Nocardia
MA Ying1,WU Shi2,HUANG Hai-Hui2,YANG Yang2,CHEN Lian-Jun1
1. Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China; 2. Institute of Antibiotics, Key Laboratory of Clinical Pharmacology of Antibiotics, National Health and Family Planning Commission, Huashan Hospital, Fudan University, Shanghai 200040, China
Abstract:Infections granuloma is a kind of chronic hyperplastic inflammation which is rarely caused by Actinomyces and Nocardia. As clinical symptoms and physical examination results of infectious granuloma caused by Actinomyces and Nocardia are similar, it is easily to lead to misdiagnosis or missed diagnosis. Here we presented a case of infectious granuloma caused by Actinomyces and a case of infectious granuloma caused by Nocardia. The final diagnosis was confirmed by pathological examination, bacterial culture and identification, and gene sequencing. We also summarized the etiology, epidemiology, clinical features, differential diagnosis, treatment and recent advances in these two infections, which could help to make the correct diagnosis without delay and choose the optimal treatment. There two infections have many similarities, and we need to distinguish them for proper therapy. The differential diagnosis with other granulomatous infections, such as tuberculosis, cutaneous sporotrichosis or chromoblastomycosis was also discussed.
马英1,吴湜2,黄海辉2,杨洋2,陈连军1. 放线菌与诺卡菌所致感染性皮肤肉芽肿的鉴别诊断及治疗[J]. 微生物与感染, 2015, 10(2): 92-97.
MA Ying1,WU Shi2,HUANG Hai-Hui2,YANG Yang2,CHEN Lian-Jun1. Differential diagnosis and treatment of infectious cutaneous granuloma caused by Actinomyces and Nocardia. JOURNAL OF MICROBES AND INFECTIONS, 2015, 10(2): 92-97.