手足口病是一种常见的由肠道病毒引起的急性传染病，其病原体主要是人肠道病毒71型（EV71）和柯萨奇病毒A16（CVA16），而CVA6感染所致手足口病相对少见。现报道1例由CVA6型手足口病致全身性疱疹并累及颈髓的病例。一般手足口病皮疹多发于手足心、臀部、膝关节和肘关节，而该患儿发病后短期内发展为全身性疱疹，并伴有神经元烯醇化酶（NSE）显著增高和颈髓核磁共振成像（MRI）影像学改变，经过抗炎、抗病毒、抗感染及支持疗法等治疗后，患儿皮疹消褪，痊愈出院。CVA6感染所致全身性疱疹并发颈髓损害较为罕见，需引起临床工作者的高度重视。

Hand, foot and mouth disease (HFMD) is a common acute infectious disease caused by enteroviruses, whose most common pathogens are human enterovirus 71 and coxsackievirus A16. Coxsackievirus A6 is relatively rare. Here a rare HFMD case complicated with systemic herpes and cervical spinal cord involved is reported. The rashes caused by HFMD were most commonly seen at the palm of hand and foot, hip, knee and elbow joint. The infant was developed to systemic herpes quickly and complicated with significantly increased neuron specific enolase and imaging changes of cervical spinal cord in magnetic resonance imaging (MRI). Under the treatment of anti-inflammatory, anti-virus, and supporting therapy, the systemic herpes disappeared and the infant fully recovered. Clinical physicians should paid more attention to this rare case caused by coxsackievirus A6.