Current research progress on microRNAs in neurodegenerative diseases including prion diseases
WEI Jing, GAO Chen
National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Beijing 102206, China
Abstract:Transmissible spongiform encephalopathies (TSEs), or prion diseases, are irreversible and fatal neurodegenerative disorders associated with the conformational conversion of cellular prion protein (PrPC), a normal cellular protein, into scrapie prion protein (PrPSc), a structural isoform that is infectious and with no effective treatment yet. MicroRNA can regulate cellular protein expression at transcriptional level and may play an critical role in the development process of central nervous system. Recent studies indicate that some specific microRNAs involved in the regulation of innate immune response and inflammation signaling pathways may also be implicated in prion diseases and provide some new insights into the treatment of prion diseases. This review highlights the progress on microRNAs in the occurrence of prion diseases and discusses the leading microRNAs in detail.
魏静,高晨. 微小RNA在朊病毒病等神经退行性疾病中的研究进展[J]. 微生物与感染, 2016, 11(2): 114-121.
WEI Jing, GAO Chen. Current research progress on microRNAs in neurodegenerative diseases including prion diseases. JOURNAL OF MICROBES AND INFECTIONS, 2016, 11(2): 114-121.