微生物与感染
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微生物与感染   2010, Vol. 5 Issue (1): 40-43     DOI:
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疫苗株病毒引起1例成人水痘的病原分离与鉴定
甘霖1; 王明丽1; 陈敬贤1,2
1.安徽医科大学微生物学教研室,合肥 230032; 2.美国哥伦比亚大学病理与细胞生物学系, 纽约10032
A case of adult varicella attributable to a vaccine virus
GAN Lin1; WANG Ming-Li1; Jason Chen1,2
1.Department of Microbiology, Anhui Medical University, Hefei 230032, China; 2.Department of Pathology & CellBiology, Columbia University, NY 10032, USA
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摘要: 本文旨在探讨1例由疫苗株病毒引起成人水痘的病例,以提高对水痘疫苗二次传播的认识。从1名23岁女性水痘患者皮肤水疱中采集水疱液,接种至人胚胎成纤维细胞,3d后观察到细胞发生病变效应。用水痘-带状疱疹病毒gE`糖蛋白单克隆抗体间接免疫荧光法鉴定,结果阳性。测序分析显示,分离到的毒株其疫苗相关的单核苷酸多态性位点与Oka疫苗株一致,为疫苗株病毒。回顾性调查显示,患者没有水痘史和疫苗接种史,病毒可能来自1名与患者直接接触的接种疫苗后发生带状疱疹的儿童。

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甘霖1
王明丽1
陈敬贤1,2
关键词 水痘-带状疱疹病毒水痘vOka 疫苗传播    
AbstractThe present paper aims to report a case of adult varicella attributable to the vOka vaccine,and to raise our awareness ofs econdary transmission through vaccination. The fluid of the skin lesions was aspirated and inoculated to human embryonic fibroblasts. The cytopathic effect (CPE) was observed 3 days later and identified by indirect immunofluorescence using monoclonal antibodies against glycoprotein E of varicella-zostervirus (VZV). The gene sequence date further revealed that the vaccine strain-associated single nucleotide polymorphisms of this isolate were the same as those included in the vOka vaccine. Both the woman and her parents denied previously having the varicella vaccine. A retrospective survey showed that the transmission may have come from a child with zoster following vaccination.

Key wordsVaricella-zostervirus    Varicella    vOka vaccine    Transmission
通讯作者: 陈敬贤; 王明丽     E-mail: jc28@columbia.edu; wangminglihf@yahoo.com.cn
引用本文:   
甘霖1; 王明丽1; 陈敬贤1,2 . 疫苗株病毒引起1例成人水痘的病原分离与鉴定[J]. 微生物与感染 , 2010, 5(1): 40-43 .
GAN Lin1; WANG Ming-Li1; Jason Chen1,2. A case of adult varicella attributable to a vaccine virus. Journal of Microbes and Infections, 2010, 5(1): 40-43 .
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