Investigation on mechanism of atherosclerosis involved by cytomegalovirus infection
LI Wanzhen1, WANG Mingli2, ZHAO Jun2
1. The First Clinical Medical College of Anhui Medical University, Hefei 230032, China; 2. Department of Microbiology, Anhui Medical University, Hefei 230032, China
Abstract：Human cytomegalovirus (HCMV) is a common human pathogen with a high infection rate up to 40%-100% worldwide. Studies have shown that HCMV-infected patients are susceptible to cardiovascular and cerebrovascular diseases, in which atherosclerosis (AS) plays a crucial role in the pathological process of multiple cardiovascular and cerebrovascular diseases. Larger epidemiologic data also indicate the presence of HCMV DNA and antibody in atherosclerotic plaques and vessel walls. Meanwhile, meta analysis has been conducted to demonstrate HCMV infection is the risk factor of atherosclerosis, which implies HCMV may be associated with the formation and development of atherosclerosis. In this review, the contribution of HCMV to vascular pathology with particular focus on atherosclerosis is reviewed.
李婉珍1，王明丽2，赵俊2. 巨细胞病毒参与动脉粥样硬化致病机制研究新进展[J]. 微生物与感染, 2017, 12(1): 50-56.
LI Wanzhen1, WANG Mingli2, ZHAO Jun2. Investigation on mechanism of atherosclerosis involved by cytomegalovirus infection. JOURNAL OF MICROBES AND INFECTIONS, 2017, 12(1): 50-56.
2017, Vol. 12 
