Antimicrobial agent susceptibilities and clinical distributions of Enterococcus faecalis and Enterococcus faecium causing bloodstream infection
CUI Zelin1, XIAO Dai1, FENG Tingting2, TANG Rong1, CHEN Wenjing1, YI Junwen1,YU Qi1, HONG Qing1, SHU Wen1, LIU Qingzhong1, LI Li1
1. Department of Clinical Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China;2. Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
Abstract:The present paper aims to retrospectively analyze the antimicrobial agent susceptibilities and clinical distributions of Enterococcus faecalis (E. faecalis) and E. faecium causing bloodstream infection in a tertiary hospital in Shanghai, and to lay a foundation for the clinical treatment of infections caused by these bacteria. The collected strains of E. faecalis and E. faecium were isolated between February 2012 and September 2016. The bacteria were identified by bioMérieux VITEK antimicrobial susceptibility testing system, and their clinical distribution and drug resistance were analyzed. Thirty E. faecalis and 17 E. faecium strains were obtained. E. faecalis strains were mainly from urology, gastroenterology and hematology departments, accounting for 13.33%, 16.67% and 10.00%, respectively. The resistance rates of E. faecalis to penicillin, ampicillin, ciprofloxacin, levofloxacin, tetracycline and erythromycin were 13.33%, 10.00%, 36.67%, 33.33%, 66.67% and 60.00%, respectively. The resistance rates of E. faecium to these antimicrobial agents were 88.24%, 82.35%, 88.24%, 76.47%, 23.53% and 70.59%, respectively. The resistance rates of E. faecium to penicillin, ampicillin, ciprofloxacin and levofloxacin were significantly higher than those of E. faecalis and the resistance rate to tetracycline was significantly lower than that of E. faecalis. Most of the E. faecium (29.41%) samples were from gastroenterology department. Both were sensitive to tigecycline, linezolid and vancomycin. However, the minimum inhibition concentration of vancomycin against E. faecium was significantly lower than that of E. faecalis. This study provided data support for the empirical treatment of infections caused by the two bacteria.
崔泽林1,肖迨1,冯婷婷2,汤荣1,陈雯静1,易峻文1,俞琦1,洪庆1,舒文1,刘庆中1,李莉1. 血流感染粪肠球菌和屎肠球菌的临床分布及耐药研究[J]. 微生物与感染, 2017, 12(1): 29-34.
CUI Zelin1, XIAO Dai1, FENG Tingting2, TANG Rong1, CHEN Wenjing1, YI Junwen1,YU Qi1, HONG Qing1, SHU Wen1, LIU Qingzhong1, LI Li1. Antimicrobial agent susceptibilities and clinical distributions of Enterococcus faecalis and Enterococcus faecium causing bloodstream infection. JOURNAL OF MICROBES AND INFECTIONS, 2017, 12(1): 29-34.