Abstract：Pyroptosis is a new form of programmed cell death depending on cysteinyl aspartate specific proteinase 1 (caspase-1). Inflammasome plays a significant role in regulating pyroptosis. Intracellular pattern recognition proteins such as nucleotide-binding oligomerization domain-like receptor (NLR) and absent in melanoma 2 (AIM2) act to their ligands and promote the assembly of inflammasome as well as the activation of caspase-1/caspase-11, then induce pyroptosis. The in-depth research on the mechanisms and correlation between pyroptosis and inflammasome contributes to the understanding of the occurrence and development of pyroptosis-related inflammatory diseases.
杨斯迪，邓奇峰，黄瑞，吴淑燕. 炎性小体激活与细胞焦亡的研究进展[J]. 微生物与感染, 2017, 12(3): 192-196.
YANG Sidi, DENG Qifeng, HUANG Rui, WU Shuyan. Research progress on inflammasome activation and pyroptosis. JOURNAL OF MICROBES AND INFECTIONS, 2017, 12(3): 192-196.