Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing 100034, China
Abstract：Caspase recruitment domain-containing protein 9 (CARD9), one of the CARD family members, is an essential adapter in myeloid cells, and is expressed in various tissues, including the spleen, liver, placenta, lung and brain. By forming a complex with Bcl-10 and mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), CARD9 mediates C-type lectin receptors (CLRs)-triggered intracellular signaling and nuclear factor κB (NF-κB) activation, which is therefore crucial in antifungal immunity. Evidence indicates that CARD9 mutations lead to increased susceptibility to various fungal infections. To date, 18 missense and nonsense CARD9 mutations have been reported in 56 patients from 14 countries, which is linked with a variety of fungal infections including Candida, Dermatophytes, Dematiaceous fungi, Aspergillus, etc. This review aims to summarize recent progress in CARD9 mutation and different fungal infections.
张逸，王晓雯，李若瑜. CARD9突变在真菌感染性疾病中的研究进展[J]. 微生物与感染, 2018, 13(4): 233-244.
ZHANG Yi, WANG Xiaowen, LI Ruoyu. Progress in CARD9 mutation and fungal infections. JOURNAL OF MICROBES AND INFECTIONS, 2018, 13(4): 233-244.
