梅毒螺旋体疫苗的研究进展

郑康1; 刘安元1; 2; 吴移谋1

doi:10.3969/j.issn.1673-6184.2019.03.007

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微生物与感染 ›› 2019, Vol. 14 ›› Issue (3) : 180-184. DOI: 10.3969/j.issn.1673-6184.2019.03.007

综述

梅毒螺旋体疫苗的研究进展

郑康¹，刘安元^1,2，吴移谋¹

作者信息 +

Vaccine development for syphilis

ZHENG Kang¹, LIU Anyuan^1,2, WU Yimou¹

Author information +

文章历史 +

摘要

梅毒是由密螺旋体苍白亚种(Treponema pallidum subsp. pallidum, Tp)感染引起的慢性系统性性传播疾病，流行于中低等收入国家。越来越多的临床病例表明清除Tp感染需要加强公共卫生筛查和治疗，而接种疫苗是预防Tp感染极有价值和首选的方法。本文概述了研制Tp疫苗的必要性，总结疫苗研究过程中候选抗原的相关信息及递送系统，分析Tp疫苗发展策略。

Abstract

Syphilis is a sexually transmitted infection caused by Treponema pallidum subsp. Pallidum (T. pallidum), Over 90% of syphilis cases occur in low- and middle-income countries. Studies indicated that elimination of T. pallidum requires enhanced public health screening, treatment and vaccination. This article provides an overview of the need for development of a syphilis vaccine, summarizes the information and delivery system and candidate antigens in development, and analyzes the development strategies for T. pallidum vaccine.

导出引用

郑康1，刘安元1,2，吴移谋1. 梅毒螺旋体疫苗的研究进展[J]. 微生物与感染. 2019, 14(3): 180-184 https://doi.org/10.3969/j.issn.1673-6184.2019.03.007

ZHENG Kang1, LIU Anyuan1,2, WU Yimou1. Vaccine development for syphilis[J]. Journal of Microbes and Infections. 2019, 14(3): 180-184 https://doi.org/10.3969/j.issn.1673-6184.2019.03.007