带状疱疹疫苗的研究进展及应用

李计来,徐静

微生物与感染 ›› 2020, Vol. 15 ›› Issue (3) : 186-191.

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微生物与感染 ›› 2020, Vol. 15 ›› Issue (3) : 186-191. DOI: 10.3969/j.issn.1673-6184.2020.03.008
综述

带状疱疹疫苗的研究进展及应用

  • 李计来,徐静
作者信息 +

Research and application of herpes zoster vaccine

  • LI Jilai, XU Jing
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文章历史 +

摘要

带状疱疹是由潜伏在体内的水痘-带状疱疹病毒再激活引起的一种急性皮肤病,主要发生于老年人和免疫力低下人群。带状疱疹是一种自限性疾病,临床主要表现为带状、成片的皮疹,而其后遗神经痛为该病中最复杂且最常见的一种不良并发症。带状疱疹的发病机制较为复杂,推测与机体的特异性T细胞免疫水平降低有关。本文就带状疱疹与T细胞之间的关系,最新疫苗研究进展进行综述,为疫苗的研发及带状疱疹的预防提供参考。

Abstract

Herpes zoster is an acute skin disease caused by relapse of varicella-zoster virus, which mainly occurs in the elderly and people with low immunity. Herpes zoster is a self-limiting disease characterized by rashes. Postherpetic neuralgia is the most complex and common adverse complication of herpes zoster. The pathogenesis of herpes zoster is complex, presumably related to T cell immunity. In this paper, the relationship between herpes zoster and T cells is reviewed, and the latest vaccine research is reviewed, which can provide reference for vaccine development and prevention of herpes zoster.

关键词

水痘-带状疱疹病毒 / 带状疱疹 / 后遗神经痛 / 发病机制 / 带状疱疹疫苗

Key words

Varicella-zoster virus / Herpes zoster / Postherpetic neuralgia / Pathogenesis / Herpes zoster vaccine

引用本文

导出引用
李计来,徐静. 带状疱疹疫苗的研究进展及应用[J]. 微生物与感染. 2020, 15(3): 186-191 https://doi.org/10.3969/j.issn.1673-6184.2020.03.008
LI Jilai, XU Jing. Research and application of herpes zoster vaccine[J]. Journal of Microbes and Infections. 2020, 15(3): 186-191 https://doi.org/10.3969/j.issn.1673-6184.2020.03.008
中图分类号: R373    R392    R186   

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