从肠道菌群角度再认识血管紧张素转换酶2在严重急性呼吸综合征冠状病毒2致病机制中的潜在作用

杨浩1; 2; 邬永琳1; 2; 荣星喻1; 2; 严雨晨1; 2; 汪慧菁3; 牛辰1; 2; 赵超1; 2

doi:10.3969/j.issn.1673-6184.2020.02.006

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微生物与感染 ›› 2020, Vol. 15 ›› Issue (2) : 104-107. DOI: 10.3969/j.issn.1673-6184.2020.02.006

综述

从肠道菌群角度再认识血管紧张素转换酶2在严重急性呼吸综合征冠状病毒2致病机制中的潜在作用

杨浩^1，2，邬永琳^1，2，荣星喻^1，2，严雨晨^1，2，汪慧菁³，牛辰^1，2，赵超^1，2

作者信息 +

Re-understanding the potential mechanism of angiotensin converting enzyme 2 in severe acute respiratory syndrome coronavirus 2 pathogenicity from the perspective of gut microbiota

YANG Hao^1，2, WU Yonglin^1，2, RONG Xingyu^1，2, YAN Yuchen^1，2, WANG Huijing³, NIU Chen^1，2, ZHAO Chao^1，2

Author information +

文章历史 +

摘要

2019冠状病毒病(coronavirus disease 2019，COVID-19)的病原学和临床表现多有报道。该病在病原学和临床表现上与发生在2003年的严重急性呼吸综合征(severe acute respiratory syndrome, SARS)有诸多相似性。本文通过对比两者异同，尝试从其共同受体血管紧张素转换酶2(angiotensin converting enzyme 2，ACE2)角度，提出并探讨患者肠道菌群可能参与其致病的潜在机制，旨在为深入探索新型冠状病毒，即严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2, SARS-CoV-2)的致病机制及加速研发重症肺炎预测指标提供一种可能的新思路。

Abstract

Since the out breaking of coronavirus induced disease 2019 (COVID-19), the etiology and clinical manifestations of the disease have been reported and analyzed. There are many similarities between the etiology and clinical manifestations of the SARS in 2003. By comparing the similarities and differences between them, this study attempts to put forward and explore the potential mechanism of gut microbiota in patients, which may participate in its pathogenesis from the perspective of the shared receptor angiotensin converting enzyme 2 (ACE2). It may provide a possible way for in-depth study of the pathogenesis of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) and the development of prediction indicators for severe pneumonia.

导出引用

杨浩1，2，邬永琳1，2，荣星喻1，2，严雨晨1，2，汪慧菁3，牛辰1，2，赵超1，2. 从肠道菌群角度再认识血管紧张素转换酶2在严重急性呼吸综合征冠状病毒2致病机制中的潜在作用[J]. 微生物与感染. 2020, 15(2): 104-107 https://doi.org/10.3969/j.issn.1673-6184.2020.02.006

YANG Hao1，2, WU Yonglin1，2, RONG Xingyu1，2, YAN Yuchen1，2, WANG Huijing3, NIU Chen1，2, ZHAO Chao1，2. Re-understanding the potential mechanism of angiotensin converting enzyme 2 in severe acute respiratory syndrome coronavirus 2 pathogenicity from the perspective of gut microbiota[J]. Journal of Microbes and Infections. 2020, 15(2): 104-107 https://doi.org/10.3969/j.issn.1673-6184.2020.02.006

中图分类号： R373.1 R378 R322.45 R34　