Construction of emergency capability and connotation of BSL-3 laboratory from new coronavirus epidemic situation
CAI Xia 1， HAN Wendong 1， SUN Zhiping 1， QIAN Yun 1， CHEN Li 2， XIE Youhua 2， QU Di 1,2
1. Biosafety Level 3 Laboratory & Shanghai Medical College Fudan University, Shanghai 200032，China；2. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS)，and Department of Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai 200032，China
摘要: 面对突发疫情，生物安全三级（biosafety level 3，BSL-3）实验室是否能及时启动并稳定、安全运行，为科研攻关提供安全、可靠的技术平台，是对实验室应急能力的考验。针对2019年12月爆发的2019冠状病毒病疫情，复旦大学BSL-3实验室在接到任务后，立即按照国家规定，启动实验室冠状病毒新实验活动申请流程。经国家合格评定认可委员会（China National Accreditation Service for Conformity Assessment，CNAS）和国家卫生委员会批准，实验室在开展实验活动一周内就从来自上海患者标本中分离到新型冠状病毒毒株，体现了平时实验室内涵建设的重要性。BSL-3实验室的内涵建设包括实验室风险评估及管理、不同人员针对性培训、设施和设备管理等生物安全管理体系的建设。本文将介绍复旦大学BSL-3实验室在应急能力及内涵建设方面的经验和体会，期望对BSL-3实验室的建设和管理提供参考。
Abstract：Facing the outbreak of COVID-19, whether biosafety level 3 (BSL-3 ) laboratory can be immediately started in time and operate safely providing a reliable platform for COVID-19 virus research and detection, is ordeal for a laboratory's ability meeting with an emergency. After receiving the mission, BSL-3 laboratory of Fudan University immediately started the application process for new coronavirus experiment activities in the lab, following the regulations of China. After obtained the approval from the National Accreditation Service for Conformity Assessment and the National Health Commission, New coronavirus strains were isolated from a sample of Shanghai COVID-19 patient within one week, which reflecting the importance of laboratory’s connotation construction in peacetime. The BSL-3 laboratory’s connotation construction includes the biosafety management systems such as risk assessment and management of laboratory, personnel training, and management of facilities and equipment, ect. In this article, we shall introduce the experience and comprehension gained from management of the Fudan University BSL-3 laboratory.
蔡霞1，韩文东1，孙志平1，钱韵1，陈力2，谢幼华2，瞿涤1,2. 从新型冠状病毒疫情看生物安全三级实验室的应急能力及内涵建设[J]. 微生物与感染, 2020, 15(4): 233-240.
Xia Cai 1，Wendong Han 1，Zhiping Sun 1，Yun Qian 1，Li Chen 2，Youhua Xie 2，Di Qu1,2. Construction of emergency capability and connotation of BSL-3 laboratory from new coronavirus epidemic situation. JOURNAL OF MICROBES AND INFECTIONS, 2020, 15(4): 233-240.
2020, Vol. 15 
