沙门菌逃逸宿主天然免疫应答机制的研究进展

徐诺1; 周帮月1; 史艺1; 潘兴元1; 2; 秦涛3; 徐正中4; 阴银燕1; 2; 4

doi:10.3969/j.issn.1673-6184.2020.05.010

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微生物与感染 ›› 2020, Vol. 15 ›› Issue (5) : 331-336. DOI: 10.3969/j.issn.1673-6184.2020.05.010

综述

沙门菌逃逸宿主天然免疫应答机制的研究进展

徐诺¹，周帮月¹，史艺¹，潘兴元^1，2，秦涛³，徐正中⁴，阴银燕^1，2，4

作者信息 +

Current research progress on host innate immune escaping by Salmonella

XU Nuo¹, ZHOU Bangyue¹, SHI Yi¹, PAN Xingyuan^1，2, QIN Tao³, XU Zhengzhong⁴, YIN Yinyan^1，2，4

Author information +

文章历史 +

摘要

沙门菌是重要的食源性病原菌，其流行严重威胁着全球公共卫生安全。天然免疫应答对于宿主抵御沙门菌的感染具有重要的作用，但是沙门菌已演化出一系列逃逸宿主天然免疫应答的策略，使其在宿主体内定植，并得以持续性感染。本文对由受体(TLRs、NLRs和RIPs)、细胞因子(IL-22和IL-4)和哺乳动物西罗莫司靶蛋白(mammalian target of rapamycin，mTOR)信号通路介导的沙门菌逃逸天然免疫应答的机制研究进展进行阐述，期望为沙门菌的预防与治疗提供新的研究思路。

Abstract

Salmonella is an important foodborne pathogen, which seriously threatens the global public health. The host innate immune response plays a significant role for resisting infection. Nowadays, Salmonella has evolved a series of strategies to escape the innate immune response for persistent infections. This review gives a detailed summarization on the new strategies of Salmonella, including receptors (TLRs, NLRs, RIPs), cytokines (IL-22 and IL-4) and mTOR signaling pathway-mediated immune escape.

导出引用

徐诺1，周帮月1，史艺1，潘兴元1，2，秦涛3，徐正中4，阴银燕1，2，4. 沙门菌逃逸宿主天然免疫应答机制的研究进展[J]. 微生物与感染. 2020, 15(5): 331-336 https://doi.org/10.3969/j.issn.1673-6184.2020.05.010

XU Nuo1, ZHOU Bangyue1, SHI Yi1, PAN Xingyuan1，2, QIN Tao3, XU Zhengzhong4, YIN Yinyan1，2，4. Current research progress on host innate immune escaping by Salmonella[J]. Journal of Microbes and Infections. 2020, 15(5): 331-336 https://doi.org/10.3969/j.issn.1673-6184.2020.05.010

中图分类号： R378.2