Current research progress on host innate immune escaping by Salmonella
XU Nuo1, ZHOU Bangyue1, SHI Yi1, PAN Xingyuan1，2, QIN Tao3, XU Zhengzhong4, YIN Yinyan1，2，4
1. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225009, Jiangsu Province, China; 2. Jiangsu Key laboratory of integrated traditional Chinese and Western Medicine for prevention and treatment of Senile Diseases, Yangzhou University, Yangzhou 225009, Jiangsu Province, China; 3. Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonosis, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, China; 4. Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, Jiangsu Province, China
摘要: 沙门菌是重要的食源性病原菌，其流行严重威胁着全球公共卫生安全。天然免疫应答对于宿主抵御沙门菌的感染具有重要的作用，但是沙门菌已演化出一系列逃逸宿主天然免疫应答的策略，使其在宿主体内定植，并得以持续性感染。本文对由受体(TLRs、NLRs和RIPs)、细胞因子(IL-22和IL-4)和哺乳动物西罗莫司靶蛋白(mammalian target of rapamycin，mTOR)信号通路介导的沙门菌逃逸天然免疫应答的机制研究进展进行阐述，期望为沙门菌的预防与治疗提供新的研究思路。
Abstract：Salmonella is an important foodborne pathogen, which seriously threatens the global public health. The host innate immune response plays a significant role for resisting infection. Nowadays, Salmonella has evolved a series of strategies to escape the innate immune response for persistent infections. This review gives a detailed summarization on the new strategies of Salmonella, including receptors (TLRs, NLRs, RIPs), cytokines (IL-22 and IL-4) and mTOR signaling pathway-mediated immune escape.
徐诺1，周帮月1，史艺1，潘兴元1，2，秦涛3，徐正中4，阴银燕1，2，4. 沙门菌逃逸宿主天然免疫应答机制的研究进展[J]. 微生物与感染, 2020, 15(5): 331-336.
XU Nuo1, ZHOU Bangyue1, SHI Yi1, PAN Xingyuan1，2, QIN Tao3, XU Zhengzhong4, YIN Yinyan1，2，4. Current research progress on host innate immune escaping by Salmonella. JOURNAL OF MICROBES AND INFECTIONS, 2020, 15(5): 331-336.
2020, Vol. 15 
