Characteristics of human immunodeficiency virus/acquired immunodeficiency syndrome patients combined with Talaromyces marneffei infection in Guangxi and application of rapid screening of Mp1p antigen
HAN Jing1,2, JIANG Zhongsheng3, WANG Gang2,5, ZHANG Peng3, HU Jiaguang3, WEI Wudi2,6, ZHANG Hong1,2, HE Jinhao1,2, LI Yueqi1,2, NING Chuanyi2,4, LIANG Hao1,2
1. Life Sciences Institute, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China; 2. Guangxi Key Laboratory of AIDS Prevention and Treatment, Nanning 530021, Guangxi Zhuang Autonomous Region, China; 3. Liuzhou People's Hospital, Liuzhou 545006, Guangxi Zhuang Autonomous Region, China; 4. School of Nursing, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China; 5. Guangxi Collaborative Innovation Center for Biomedicine, Nanning 530021, Guangxi Zhuang Autonomous Region, China; 6. School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Abstract：The present paper aims to investigate the characteristics of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients combined with Talaromyces marneffei (TM) infection in Guangxi Zhuang Autonomous Region, and to evaluate a TM antigen detection kit. The information of 200 HIV/AIDS patients including 20 patients combined with TM infection from Liuzhou People’s Hospital was collected. The overall TM infection rate was 10%, and TM infection rate was higher in the patients with lower CD4＋ T counts. In the patients with CD4＋ T counts ≤50/μL, TM infection rate could be as high as 29%. The CD4＋ T count, lymphocyte, hemoglobin, albumin, and platelet levels in HIV/AIDS patients combined with TM infection were significantly lower than those HIV/AIDS patients without TM infection (P<0.001). In contrast aspartate aminotransferase (AST), AST/alanine aminotransferase (ALT) and D-dimer were significantly increased in HIV/AIDS patients combined with TM infection (P<0.05). A TM antigen detection kit was used to detect TM in 118 plasma samples and 111 pharyngeal swab samples, and the results were compared with pathogenic culture results. For plasma samples, the sensitivity was 80% (95% CI: 51.1-94.7) and the specificity was 97.1% (95% CI: 91.1-99.2). For pharyngeal swab samples, the sensitivity was 41.7% (95% CI: 16.5-71.4) and the specificity was 100% (95% CI: 0.95-1). The results showed that the TM antigen detection kit has good sensitivity and high specificity for plasma sample detection, which maybe suitable for the clinical screening of TM infection. It is recommended that HIV/AIDS patients with low CD4＋ T counts should be screened for Mp1p antigen as soon as possible for early detection and early treatment, and to reduce the mortality.
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HAN Jing, JIANG Zhongsheng, WANG Gang, ZHANG Peng，HU Jiaguang, WEI Wudi, ZHANG Hong, HE Jinhao，LI Yueqi, NING Chuanyi, LIANG Hao. Characteristics of human immunodeficiency virus/acquired immunodeficiency syndrome patients combined with Talaromyces marneffei infection in Guangxi and application of rapid screening of Mp1p antigen. JOURNAL OF MICROBES AND INFECTIONS, 2021, 16(1): 19-25.
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2021, Vol. 16 
