Research progress on the anti-inflammatory effect of tumor necrosis factor alpha stimulated gene/inducible protein 6
SHU Jinhui1, ZHANG Junling2, ZHAO Jun2, WANG Mingli2
1. The First Clinical Medical College, Anhui Medical University, Hefei 230032, Anhui Province, China; 2. Department of Microbiology, Anhui Medical University, Hefei 230032, Anhui Province, China
Abstract:Inflammatory injury is a key pathological factor for many clinical diseases, which can often cause serious complications or death. However, traditional clinical methods are rare and with limited therapeutic effects. Recent studies show that tumor necrosis factor alpha stimulated gene inducible protein 6 (TSG-6) can participate in many inflammatory processes through its association with different ligands in vivo, and play an important role in anti-inflammatory and promoting extracellular matrix remodeling. In this review, we focus mainly on the basic biological characteristics and mechanism of TSG-6, and summarize its anti-inflammatory effects in pathologic scars, neuroinflammation, atherosclerosis and joint inflammation.
束金辉,张俊玲,赵俊,王明丽. 肿瘤坏死因子α刺激基因/诱导蛋白-6的抗炎作用研究进展[J]. 微生物与感染, 2021, 16(1): 57-62.
SHU Jinhui, ZHANG Junling, ZHAO Jun, WANG Mingli. Research progress on the anti-inflammatory effect of tumor necrosis factor alpha stimulated gene/inducible protein 6. JOURNAL OF MICROBES AND INFECTIONS, 2021, 16(1): 57-62.
Lee T H, Lee G W, Ziff E B, et al. Isolation and characterization of eight tumor necrosis factor-induced gene sequences from human fibroblasts[M]. 10.United States
:1990.1982-1988.
[2]
Milner C M, Day A J. TSG-6: a multifunctional protein associated with inflammation[J]. Journal of cell science,2003,116(Pt 10):1863-1873.
[3]
Milner C M, Higman VA, Day AJ. TSG-6: a pluripotent inflammatory mediator?[J]. Biochemical Society transactions,2006,34(Pt 3):446.
[4]
Day A J, Milner C M. TSG-6: A multifunctional protein with anti-inflammatory and tissue-protective properties[J]. Matrix Biology,2019,78-79:60-83.
[5]
Kohda D, Morton C J, Parkar A A, et al. Solution Structure of the Link Module: A Hyaluronan-Binding Domain Involved in Extracellular Matrix Stability and Cell Migration[J]. Cell,1996,86(5):767-775.
[6]
Tan K T, Baildam A D, Juma A, et al. Hyaluronan, TSG-6, and inter-alpha-inhibitor in periprosthetic breast capsules: reduced levels of free hyaluronan and TSG-6 expression in contracted capsules[J]. Aesthet Surg J,2011,31(1):47-55.
[7]
Lesley J, Gál I, Mahoney D J, et al. TSG-6 Modulates the Interaction bet-ween Hyaluronan and Cell Surface CD44[J]. Journal of Biological Chemistry,2004,279(24):25745-25754.
[8]
Mcdonald B, Mcavoy E F, Lam F, et al. Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids[J]. Journal of Experimental Medicine,2008,205(4):915-927.
[9]
Kui L, Chan G C, Lee P P W. TSG-6 Downregulates IFN-Alpha and TNF-Alpha Expression by Suppressing IRF7 Phosphorylation in Human Plasmacytoid Dendritic Cells[J]. Mediators of Inflammation,2017,2017:1-12.
[10]
Choi H, Lee R H, Bazhanov N, et al. Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages[J]. Blood,2011,118(2):330-338.
[11]
Shaw T J, Kishi K, Mori R. Wound-associated skin fibrosis: mechanisms and treatments based on modulating the inflammatory response[J]. Endocrine, metabolic & immune disorders drug targets,2010,10(4):320.
[12]
Wang H, Chen Z, Li X, et al. Anti-inflammatory cytokine TSG-6 inhibits hypertrophic scar formation in a rabbit ear model[J]. European Journal of Pharmacology,2015,751:42-49.
X-Y Li,T Li,X-J Li,J-N Wang,Z Chen. TSG-6 Induces Apoptosis of Human Hypertrophic Scar Fibroblasts via Activation of the Fas/FasL Signalling Pathway[J]. Folia Biologica,2018,64(5/6).
[17]
Boche D, Perry V H, Nicoll J A R. Review: Activation patterns of microglia and their identification in the human brain[J]. Neuropathology and Applied Neurobiology,2013,39(1):3-18.
[18]
Hu X, Leak R K, Shi Y, et al. Microglial and macrophage polarization—new prospects for brain repair[J]. Nature Reviews Neurology,2015,11(1):56-64.
[19]
Liu Y, Zhang R, Yan K, et al. Mesenchymal stem cells inhibit lipopolysaccharide-induced inflammatory responses of BV2 microglial cells through TSG-6[J]. Journal of neuroinflammation,2014,11(1):135.
[20]
Liu Y, Zeng R, Wang Y, et al. Mesenchymal stem cells enhance microglia M2 polarization and attenuate neuroinflammation through TSG-6[J].Brain Rese-arch,2019,1724:146422.
[21]
Qiu J, Nishimura M, Wang Y, et al. Early Release of HMGB-1 from Neurons after the Onset of Brain Ischemia[J]. Journal of Cerebral Blood Flow & Metabolism,2007,28(5):927-938.
[22]
Caso J R, Pradillo J M, Hurtado O, et al. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke[J]. Circulation,2007,115(12):1599-1608.
Hansson G K, Libby P. The immune response in atherosclerosis: a double-edged sword[J]. Nature Reviews Immunology,2006,6(7):508-519.
[25]
Cao T V, La M, Getting S J, et al. Inhibitory Effects of TSG-6 Link Module on Leukocyte-Endothelial Cell Interactions In Vitro and In Vivo[J]. Microcirculation,2004,11(7):615-624.
[26]
Dyer D P, Thomson J M, Hermant A, et al. TSG-6 Inhibits Neutrophil Migration via Direct Interaction with the Chemokine CXCL8[J]. The Journal of Immunology,2014,192(5):2177.
[27]
Ye L, Mora R, Akhayani N, et al. Growth Factor and Cytokine-Regulated Hyaluronan-Binding Protein TSG-6 Is Localized to the Injury-Induced Rat Neointima and Confers Enhanced Growth in Vascular Smooth Muscle Cells[J]. Circulation Research,1997,81(3):289-296.
[28]
Watanabe R, Sato Y, Ozawa N, et al. Emerging Roles of Tumor Necrosis Factor-Stimulated Gene-6 in the Pathophysiology and Treatment of Atherosclerosis[J]. International Journal of Molecular Sciences,2018,19(2):465.
[29]
Watanabe R, Watanabe H, Takahashi Y, et al. Atheroprotective Effects of Tumor Necrosis Factor-Stimulated Gene-6[J]. JACC: Basic to Translational Science,2016,1(6):494-509.
[30]
Bayliss M T, Howat S L T, Dudhia J, et al. Up-regulation and differential expression of the hyaluronan-binding protein TSG-6 in cartilage and synovium in rheumatoid arthritis and osteoarthritis[J]. Osteoarthritis and Cartilage,2001,9(1):42-48.
[31]
Szántó S, Bárdos T, Gál I, et al. Enhanced neutrophil extravasation and rapid progression of proteoglycan-induced arthritis in TSG-6-knockout mice[J]. Arthritis & Rheumatism,2004,50(9):3012-3022.
[32]
Bárdos T, Kamath R V, Mikecz K, et al. Anti-Inflammatory and Chondroprotective Effect of TSG-6 (Tumor Necrosis Factor-α-Stimulated Gene-6) in Murine Models of Experimental Arthritis[J]. The American Journal of Pathology,2001,159(5):1711-1721.
[33]
Mahoney D J, Mikecz K, Ali T, et al. TSG-6 Regulates Bone Remodeling through Inhibition of Osteoblastogenesis and Osteoclast Activation[J]. Journal of Biological Chemistry,2008,283(38):25952-25962.
[34]
Bryan C, Sammour I, Guerra K, et al. TNFα-stimulated protein 6 (TSG-6) reduces lung inflammation in an experimental model of bronchopulmonary dysplasia[J]. Pediatric Research,2019,85(3):390-397.
[35]
Chaubey S, Thueson S, Ponnalagu D, et al. Early gestational mesenchymal stem cell secretome attenuates experimental bronchopulmonary dysplasia in part via exosome-associated factor TSG-6[J]. Stem Cell Research & Therapy,2018,9(1).
[36]
Jha K A, Pentecost M, Lenin R, et al. TSG-6 in conditioned media from adipose mesenchymal stem cells protects against visual deficits in mild traumatic brain injury model through neurovascular modulation[J]. Stem Cell Research &Therapy,2019,10(1).
[37]
Chen Y, Tang X, Li P, et al. Bone Marrow Derived Mesenchymal Stromal Cells Ameliorate Ischemia/Reperfusion Injury-Induced Acute Kidney Injury in Rats via Secreting Tumor Necrosis Factor-Inducible Gene 6 Protein[J]. BioMed Research International,2019,2019:1-12.