Research progress on the anti-inflammatory effect of tumor necrosis factor alpha stimulated gene/inducible protein 6
SHU Jinhui1, ZHANG Junling2, ZHAO Jun2, WANG Mingli2
1. The First Clinical Medical College, Anhui Medical University, Hefei 230032, Anhui Province, China; 2. Department of Microbiology, Anhui Medical University, Hefei 230032, Anhui Province, China
Abstract：Inflammatory injury is a key pathological factor for many clinical diseases, which can often cause serious complications or death. However, traditional clinical methods are rare and with limited therapeutic effects. Recent studies show that tumor necrosis factor alpha stimulated gene inducible protein 6 (TSG-6) can participate in many inflammatory processes through its association with different ligands in vivo, and play an important role in anti-inflammatory and promoting extracellular matrix remodeling. In this review, we focus mainly on the basic biological characteristics and mechanism of TSG-6, and summarize its anti-inflammatory effects in pathologic scars, neuroinflammation, atherosclerosis and joint inflammation.
束金辉1，张俊玲2，赵俊2，王明丽2. 肿瘤坏死因子α刺激基因/诱导蛋白-6的抗炎作用研究进展[J]. 微生物与感染, 2021, 16(1): 57-62.
SHU Jinhui1, ZHANG Junling2, ZHAO Jun2, WANG Mingli2. Research progress on the anti-inflammatory effect of tumor necrosis factor alpha stimulated gene/inducible protein 6. JOURNAL OF MICROBES AND INFECTIONS, 2021, 16(1): 57-62.
2021, Vol. 16 
