Abstract：Fusobacterium nucleatum is a kind of symbiotic bacteria in human, especially enriched in the oral cavity, and could lead to opportunistic infections in certain cases. Recently, the relationship between Fusobacterium nucleatum and colorectal cancer (CRC) has become a research focus. Numerous clinical studies have shown that Fusobacterium nucleatum is more abundant in CRC, and further studies on animals have proved that Fusobacterium nucleatum can promote the onset and progression of CRC, and chemoresistance to CRC through various mechanisms. We summarized the evidence of the association between Fusobacterium nucleatum and CRC, and provided a comprehensive review of the currently existing mechanisms of Fusobacterium nucleatum promoting CRC.
