No-antibiotic therapies of Pseudomonas aeruginosa infection
TANG Xiaoli1, FENG Yi2, ZHUO Shaoyuan2, LE Ning2, SHANG Liguo2
1. School of Nursing, Guangxi University of Chinese Medicine, Nanning 530200, Guangxi Zhuang autonomous region, China; 2. School of Basic Medical Science,Guangxi University of Chinese Medicine, Nanning 530200, Guangxi Zhuang autonomous region, China
Abstract:Pseudomonas aeruginosa (P. aeruginosa) is a ubiquitous human pathogen causing different infections. Antibiotic therapy is the first clinical option for the infections caused by P. aeruginosa. Unfortunately, empiric antibiotic therapy may not work due to drug resistance. Non-antibitoc therapies for P. aeruginosa infections are getting extensive attention and promising research is being conducted. This review will focus on the progresses of non-antibitoc therapies including antigen-antibody immunotherapy, phage therapy and anti-virulence therapy. The problems of these new therapies in the clinical treatment and the possible strategies to overcome them are also discussed.