铜绿假单胞菌是引起多种人体感染的常见致病菌，目前主要采用抗生素治疗铜绿假单胞菌感染。由于铜绿假单胞菌能对多种抗生素产生抗性，导致传统的抗生素治疗面临非常大的挑战。因而铜绿假单胞菌感染的非抗生素治疗方法受到了广泛重视，并取得了可喜的研究进展。本文从抗原抗体免疫疗法、噬菌体疗法、抗毒力因子疗法三个方面就铜绿假单胞菌的非抗生素治疗近年来取得的研究进展进行论述，讨论非抗生素疗法面临的难题以及可能解决的方法。

Pseudomonas aeruginosa (P. aeruginosa) is a ubiquitous human pathogen causing different infections. Antibiotic therapy is the first clinical option for the infections caused by P. aeruginosa. Unfortunately, empiric antibiotic therapy may not work due to drug resistance. Non-antibitoc therapies for P. aeruginosa infections are getting extensive attention and promising research is being conducted. This review will focus on the progresses of non-antibitoc therapies including antigen-antibody immunotherapy, phage therapy and anti-virulence therapy. The problems of these new therapies in the clinical treatment and the possible strategies to overcome them are also discussed.