Advances in the study of amphotericin B: mechanisms of antifungal action and resistance mechanisms in pathogenic Aspergillus terreus
LIANG Tianyu, LI Ruoyu, LIU Wei
Department of Dermatology and Venerology, Peking University First Hospital, National Clinical Research Center for Skin and Immune Diseases, Research Center for Medical Mycology, Peking University, Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing 100034, China
Abstract:Amphotericin B (AMB) is a classical polyene antifungal agent with powerful and broad-spectrum activity against pathogenic fungi, and less likely to be resistant. Aspergillus terreus, a clinically common pathogenic Aspergillus, is gaining attention due to intrinsic AMB resistance. At present, the mode of antifungal action of AMB needs to be further elucidated, and little is known about the mechanism of AMB resistance. This review addresses the novel mode of action by which AMB induces increased endogenous reactive oxygen species (ROS) production in Aspergillus terreus. Also, the role of stress adaptation pathways (heat shock protein 90, heat shock protein 70, and calcineurin), ROS scavenging enzymes, as well as mitochondrial function in the mechanisms of AMB resistance in Aspergillus terreus is highlighted. These novel findings are of great significance in understanding both action and resistance mechanism of AMB in other pathogenic Aspergilli spp. with clinical importance.
梁天宇,李若瑜,刘伟. 两性霉素B抗真菌作用机制与病原性土曲霉对其耐药机制的研究进展[J]. 微生物与感染, 2021, 16(3): 189-195.
LIANG Tianyu, LI Ruoyu, LIU Wei. Advances in the study of amphotericin B: mechanisms of antifungal action and resistance mechanisms in pathogenic Aspergillus terreus. JOURNAL OF MICROBES AND INFECTIONS, 2021, 16(3): 189-195.