本研究旨在探讨脓毒症患者中血清可溶性髓样细胞触发受体1(soluble myeloid cell trigger receptor 1，sTREM1)、降钙素原(procalcitonin，PCT)、核因子κB(nuclear factor­κB，NF­κB)水平与肠道菌群失衡的相关性。将2016年5月—2019年6月重庆市綦江区人民医院消化内科收治的86例脓毒症患者纳入脓毒症组，同期收治的未并发脓毒症患者50例纳入非脓毒症组，同期到本院进行体检的健康人50例纳入对照组，比较3组之间肠道菌群α多样性、肠道菌群含量，以及血清sTREM1、PCT、NF­κB水平的差异，并进行Spearman相关性分析。结果显示，脓毒症组Ace指数、Chao指数、Shannon指数显著低于非脓毒症组和对照组，Simpson指数显著高于非脓毒症组和对照组(P<0.05)；脓毒症组类杆菌、双歧杆菌含量显著低于非脓毒症组和对照组，肠球菌、大肠埃希菌、葡萄球菌含量显著高于非脓毒症组和对照组(P<0.05)；脓毒症组血清sTREM1、PCT、NF­κB水平显著高于非脓毒症组和对照组(P<0.05)。Spearman相关性分析显示，脓毒症患者中sTREM1、PCT、NF­κB水平与Ace指数、Chao指数、Shannon指数均呈负相关(P<0.05)，与Simpson指数呈正相关(P<0.05)。结果提示，脓毒症患者中血清sTREM1、PCT、NF­κB水平与肠道菌群失衡有关联。

The purpose of the present study is to explore the correlation between serum soluble myeloid cell trigger receptor 1 (sTREM1), procalcitonin (PCT), nuclear factor­κB (NF­κB) levels and intestinal microflora disorders in the patients with sepsis. A total of 86 patients with sepsis from Department of Digestive Medicine, Chongqing Qijiang District People’s Hospital were enrolled in the sepsis group. Fifty patients without sepsis admitted to the hospital during the same period were enrolled in the non­sepsis group, and 50 healthy people who underwent medical examinations in the hospital during the same period were enrolled in the control group. The alpha diversity and composition of intestinal flora, levels of serum sTREM1, PCT, NF­κB were analyzed. Spearman correlation analysis was performed. The results showed that Ace index, Chao index and Shannon index in the sepsis group were significantly lower, and Simpson index was significantly higher than those in the non­sepsis group and control group (P<0.05). The contents of Bacteroides and Bifidobacterium in the sepsis group were significantly lower, and the contents of Enterococcus, Escherichia coli, Staphylococcus were significantly higher than those in the non­sepsis group and control group (P<0.05). Serum sTREM1, PCT and NF­κB levels in the sepsis group were significantly higher than those in the non­sepsis group and control group (P<0.05). Spearman correlation analysis showed that serum sTREM1, PCT, NF­κB levels were negatively correlated with Ace index, Chao index, Shannon index (P<0.05), and positively correlated with Simpson index (P<0.05). It is suggested that serum sTREM1, PCT and NF­κB levels are associated with intestinal dysbacteriosis in the patients with sepsis.