Regulation of interleukins on anti-tuberculosis immune response of lymphocytes
LIU Xi1，2， SHEN Hongbo2， WANG Feifei3， XU Junfa1
1. Department of Clinical Immunology, Institute of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, Guangdong Province, China; 2. Clinic and Research Center of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China; 3. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), and Department of Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
Abstract：Cytokines of interleukins (IL) can regulate the differentiation, proliferation and effector function of immune cells. The expression of specific interleukins induced by Mycobacterium tuberculosis (Mtb) antigens could be used to characterize Mtb infection in humans. In host’s anti-tuberculosis immune defense, interleukins can directly regulate the bactericidal activity of phagocytes to inhibit intracellular Mtb growth. Interleukins can also induce the proliferation and effect function of T cells to further enhance the bactericidal activity of phagocytes. Some interleukins are being tested in clinical trials as an adjuvant immunotherapy for tuberculosis treatment. Here, this study reviewed the latest research progresses of interleukins regulating anti-tuberculosis immune response of lymphocytes, and discussed the rationale for the development of interleukins as potential adjunctive treatment in tuberculosis.
刘曦1, 2，沈洪波2，王菲菲3，徐军发1. 结核免疫应答相关白细胞介素的作用机制研究进展[J]. 微生物与感染, 2022, 17(1): 41-46.
LIU Xi1，2， SHEN Hongbo2， WANG Feifei3， XU Junfa1. Regulation of interleukins on anti-tuberculosis immune response of lymphocytes. JOURNAL OF MICROBES AND INFECTIONS, 2022, 17(1): 41-46.