随着人们对肠道菌群研究的深入，越来越多的证据表明肠道菌群失调与许多慢性疾病的发生和进展密切相关。目前，采用益生菌治疗疾病已成为国际热点，而嗜黏蛋白阿克曼菌(Akkermansia muciniphila，A. muciniphila)作为人类肠道黏液层中的常见定植菌，逐渐被认为是二代益生菌中有前途的候选者。本文综述了A. muciniphila对慢性疾病的改善作用及其可能机制，从而为疾病治疗提供新思路。

As the research progresses on intestinal flora, more and more evidences show that the imbalance of intestinal flora is closely related to the occurrence and progression of many chronic diseases. Probiotic treatment has become a worldwide hotspot, and Akkermansia muciniphlia (A. muciniphila), a common colonizer in the mucous layer of human intestines, has gradually been regarded as a promising candidate for the next-generation probiotics. The present paper summarizes the ameliorating effects of A. muciniphila on chronic diseases and the possible mechanisms, providing a new idea for the treatment of diseases.