Abstract：【Abstract】Objective: To investigate the diagnosis and treatment of neonatal Acinetobocter johnsonii (AJ) infection by summarizing the clinical characteristics and treatment outcome of neonatal sepsis caused by AJ. Method: The clinical details of 2 cases of neonatal AJ sepsis were retrospectively analyzed, and the relevant literature was consulted for analysis. Result: Two cases with gestational age of 26+5 weeks and 34 weeks, birth weight of 1050 g and 1800 g, developed sepsis on postnatal days 21 and 23, separately, which were confirmed to have AJ infection by blood culture and were discharged uneventfully after 40 and 36 days of hospitalization after treatment. Conclusion: AJ is a rare human infectious pathogen. The diagnosis depends on blood culture. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry can help AJ identification. The selection of antibacterial drugs should be based on the results of drug susceptibility testing and MIC values, as well as the physiological state of the children themselves.
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