突如其来的严重急性呼吸综合征冠状病毒2奥密克戎变异株感染暴发，不仅影响上海整体医疗模式的运作，更是对上海定点医院开展救治工作，落实医疗核心制度，保障患者安全提出了巨大挑战。复旦大学附属华山医院宝山院区作为新型冠状病毒肺炎(coronavirus disease 2019，COVID-19)患者收治的定点医院，根据自身的实际情况，形成“院级医疗核心管理工作制度”“专科化救治保障相关工作制度”“其他新冠相关专项工作制度”等多层级管理制度。在有限的医疗资源下，把灵活、智慧落实核心制度作为定点医院工作的重要环节，持续改进并形成了一系列管理模式。本文为最大限度保障患者安全、妥善应对突发公共卫生事件提供了实践经验与参考。

The outbreak of Omicron variant infectious disease not only affects Shanghai’s overall medical operation mode, but also generates enormous challenges and roadblocks of the implementation of treatment work, the accomplishment of the core medical systems and regimes, and the protection of patient safety to designated hospitals in Shanghai. As one of designated hospitals of Shanghai, the Baoshan Campus of Huashan Hospital has formed various multi-level management systems under the current circumstance, including the “hospital-level medical core management work system”， “specialized treatment guarantee-related work system” and “new crown-related special work system”. With the limited medical resources, Huashan Hospital regards flexible and intelligent implementation of the core system as an important task, and has built a series of management models. This paper has illustrated practical experience, and has provided reference for the purpose of maximizing the protection of patient’s safety and properly reacting during the outbreak of epidemic.