Laboratory testing technologies of Creutzfeldt-Jakob disease
WANG Huanru1, TENG Zheng1, SHI Qi2, ZHANG Xi1
1. Pathogen Testing Center, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China; 2. National Institute for Viral Disease Control and Prevention, Center for Disease Control and Prevention of China, Beijing 102206, China
Abstract：Creutzfeldt-Jakob disease(CJD) is the most common prion disease in human beings. Due to the infectivity and 100% fatality rate of CJD, early diagnosis is critical for disease control and prevention. Diagnosis of CJD needs combined analysis of both clinical features and laboratory testing results. The current review mainly focuses on the laboratory testing technologies of CJD including direct and indirect tests of prion, detection of the disease markers, as well as the analysis of disease-related gene PRNP, aiming to provide technical references for the normalization and development of CJD laboratory testing.
2022, Vol. 17 
