Research progress on gene-edited intestinal bacteria in the treatment of colorectal cancer
LIU Yincong1, 2, ZHANG Yuting2, WANG Yilan2, LIU Min2, WANG Wenxue2, GENG Jiawei2
1. The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan Province, China; 2. Department of Infectious Diseases and Liver Diseases, The First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan Province, China
Abstract：Colorectal cancer (CRC) is a common digestive malignant tumor in China. A large number of studies have confirmed that intestinal flora disorders can promote the occurrence and development of CRC through a variety of mechanisms, and regulating intestinal flora can exert certain auxiliary therapeutic effects on CRC. But the treatment still has certain limitations and side effects. Studies have shown that the clinical treatment of CRC by engineered and edited intestinal bacteria through gene editing may have potential application values. In this paper, the current research progress on gene-editing for modifying intestinal bacteria in the treatment of CRC is reviewed, aiming to explore the possibility of gene-edited intestinal bacteria in the treatment of CRC in the future.
刘印聪1, 2，张玉亭2，王一岚2，刘敏2，王文学2，耿嘉蔚2. 基因编辑肠道细菌在结直肠癌治疗中的研究进展[J]. 微生物与感染, 2023, 18(2): 115-122.
LIU Yincong1, 2, ZHANG Yuting2, WANG Yilan2, LIU Min2, WANG Wenxue2, GENG Jiawei2. Research progress on gene-edited intestinal bacteria in the treatment of colorectal cancer. JOURNAL OF MICROBES AND INFECTIONS, 2023, 18(2): 115-122.
2023, Vol. 18 
