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Abstract Abstract: To explore the role of iron ion in the host process of Neisseria gonorrhoeae infection, and to provide ideas for the prevention and treatment of gonorrhea. Consult the four major databases of CNKI, Wanfang, VIP and PubMed to search for the regulatory role of iron ion in the host process of Neisseria gonorrhoeae infection and its correlation with drug resistance. The analysis from the aspects of Neisseria gonorrhoeae adhesion, competition for iron ion, resistance to host killing and human-to-human transmission showed that Neisseria gonorrhoeae decreased its sensitivity to host antibacterial substances by reducing the content of iron in the bacteria. When the iron content is low, Neisseria gonorrhoeae can promote the survival and dissemination of Neisseria gonorrhoeae by up-regulating the expression of iron uptake gene and secreting transferrin / lactoferrin binding protein, iron carrier, MpeR and other substances. As a result, iron ions play an important role in Neisseria gonorrhoeae basic survival needs, resistance to killing, spread and so on. By regulating the concentration of iron ions inside and outside the bacteria, the disease prevention effect can be enhanced.
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Received: 25 April 2023
Published: 01 January 2023
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[1] |
蒋法兴; 王千秋.淋病的诊疗[J].皮肤科学通报, 2021, 38(01):30-34
|
[2] |
Wang LC, Litwin M, Sahiholnasab Z, etal.Neisseria gonorrhoeae Aggregation Reduces Its Ceftriaxone Susceptibility.[J].Antibiotics (Basel), 2018, 7(2):48-48
|
[3] |
Hu LI, Stohl EA, Seifert HS.The Neisseria gonorrhoeae type IV pilus promotes resistance to hydrogen peroxide- and LL-37-mediated killing by modulating the availability of intracellular, labile iron.[J].PLoS pathogens, 2022, 18(6):e1010561-e1010561
|
[4] |
齐越.淋病奈瑟菌免疫逃逸机制研究进展[J].医学综述, 2013, 19(1):13-15
|
[5] |
郑晓丽, 尹跃平, 周可.淋球菌抵抗中性粒细胞杀伤机制研究进展[J].中国艾滋病性病, 2020, 26(03):327-330
|
[6] |
陈春梅; 葛品; 郭翀.人体铁代谢及其调控因素[J].基础医学与临床, 2022, 42(5):818-823
|
[7] |
秦源, 贾战生, 张颖.铁稳态与宿主防御[J].转化医学电子杂志, 2017, 4(4):1-4
|
[8] |
Sangkhae V, Nemeth E.Regulation of the iron homeostatic hormone hepcidin[J].Adv Nutr, 2017, 8(1):126-136
|
[9] |
Zeidan RS, Han SM, Leeuwenburgh C, Xiao R.Iron homeostasis and organismal aging.[J].Ageing Res Rev, 2021, 72(Suppl 1):101510-101510
|
[10] |
Nemeth E, Ganz T.Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis.[J].Int J Mol Sci, 2021, 22(12):6493-
|
[11] |
米海潮, 崔芳, 杜玉涛等.慢性病贫血铁代谢调节机制的研究进展[J].生理学报, 2022, 74(04):639-647
|
[12] |
Zughaier SM, Kandler JL, Shafer WM.Neisseria gonorrhoeae modulates iron-limiting innate immune defenses in macrophages.[J].PLoS One, 2014, 9(1):e87688-
|
[13] |
Callaghan MM, Klimowicz AK, Shockey AC, etal.Transcriptional and Translational Responsiveness of the Neisseria gonorrhoeae Type IV Secretion System to Conditions of Host Infections.[J].Infect Immun, 2021, 89(12):e0051921-
|
[14] |
Zola TA, Strange HR, Dominguez NM, etal.Type IV secretion machinery promotes ton-independent intracellular survival of Neisseria gonorrhoeae within cervical epithelial cells.[J].Infect Immun, 2010, 78(6):2429-37-
|
[15] |
Salgado-Pabón W, Du Y, Hackett KT, etal.Increased expression of the type IV secretion system in piliated Neisseria gonorrhoeae variants.[J].J Bacteriol., 2010, 192(7):1912-20-
|
[16] |
Ramsey ME, Woodhams KL, Dillard JP.The Gonococcal Genetic Island and Type IV Secretion in the Pathogenic Neisseria. 2:61[J].Front Microbiol, 2011, 2:61-
|
[17] |
马玥; 宋楠楠; 李冰清.细菌铁摄取调节蛋白的研究进展[J].中国病原生物学杂志, 2021, 16(01):117-121
|
[18] |
Yu C, McClure R, Nudel K, etal.Characterization of the Neisseria gonorrhoeae Iron and Fur Regulatory Network.[J].J Bacteriol, 2016, 198(16):2180-91-
|
[19] |
Stoudenmire JL, Greenawalt AN, Cornelissen CN.Stealthy microbes: How Neisseria gonorrhoeae hijacks bulwarked iron during infection.[J].Front Cell Infect Microbiol, 2022, 12:1017348-
|
[20] |
Jaworska K, Ludwiczak M, Murawska E, Raczkowska A, Brzostek K.The Regulator OmpR in Yersinia enterocolitica Participates in Iron Homeostasis by Modulating Fur Level and Affecting the Expression of Genes Involved in Iron Uptake.[J].Int J Mol Sci, 2021, 22(3):1475-
|
[21] |
叶智鸧.铁离子对大肠杆菌外膜蛋白OmpW的调控机制研究[J].浙江理工大学, 2015, :-
|
[22] |
陈绍椿, 张瑾, 王千秋等.耐药淋球菌的流行、防治与展望[J].皮肤科学通报, 2021, 38(01):35-42
|
[23] |
Mercante AD, Jackson L, Johnson PJ, etal.MpeR regulates the mtr efflux locus in Neisseria gonorrhoeae and modulates antimicrobial resistance by an iron-responsive mechanism.[J].Antimicrob Agents Chemother, 2012, 56(3):1491-501
|
[24] |
Escobar A, Rodas PI, Acu?a-Castillo C.Macrophage-Neisseria gonorrhoeae Interactions: A Better Understanding of Pathogen Mechanisms of Immunomodulation.[J].Front Immunol, 2018, 9:3044-
|
[25] |
马若楠.铁死亡压力在巨噬细胞对抗胞内菌过程中的作用及机制研究[D]..扬州大学, 2022, :-
|
[26] |
门晋名.铁载体高产菌的筛选及铁载体的分离纯化[D].青岛科技大学, 2013.
|
[27] |
梁美玲, 黄麟杰, 刘俏, 等.病原真菌中潜在的铁死亡通路:功能与研究展望[J].微生物学通报, 2021, 48(11):4387-4397
|
[28] |
刘君; 侯劲松; 孟影; 等.铁载体分子偶联抗生素药物研究进展[J].有机化学, 2020, 40(10):3026-3043
|
[29] |
潘威, 孔启迪, 杨玉社, 许斌.抗革兰阴性菌药物研究进展[J].中国医药工业杂志, 2021, 52(06):742-756
|
[30] |
张利; 刘马峰; 程安春.铁载体-抗生素耦合物:一种新型的抗菌制剂[J].[J].微生物学通报, 2016, 43(7):1598-1604
|
[31] |
马兴换; 刘楠楠.新型铁载体抗生素头孢地尔的研究[J].[J].国外医药(抗生素分册), 2020, 41(4):335-338
|
[32] |
Quillin SJ, Seifert HS.Neisseria gonorrhoeae host adaptation and pathogenesis.[J].Nat Rev Microbio, 2018, 16(4):226-240
|
[33] |
Mngomezulu K, Mzobe GF, Mtshali A, etal.Recent Semen Exposure Impacts the Cytokine Response and Bacterial Vaginosis in Women.[J].Front Immunol, 2021, 12:695201-
|
[34] |
Gong Z, Tang MM, Wu X, etal.Arginine- and Polyamine-Induced Lactic Acid Resistance in Neisseria gonorrhoeae.[J].PLoS One, 2016, 11(1):e0147637-
|
[35] |
Vielfort K, Sj?linder H, Roos S, etal.Adherence of clinically isolated lactobacilli to human cervical cells in competition with Neisseria gonorrhoeae.[J].Microbes Infect, 2008, 10(12-13):1325-34
|
[36] |
Jerse AE, Crow ET, Bordner AN, etal.Growth of Neisseria gonorrhoeae in the female mouse genital tract does not require the gonococcal transferrin or hemoglobin receptors and may be enhanced by commensal lactobacilli.[J].Infect Immun, 2002, 70(5):2549-2558
|
[37] |
O' Hanlon DE, Lanier BR, Moench TR, etal.Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli.[J].BMC Infect Dis, 2010, 10:120-
|
[38] |
Breshears LM, Edwards VL, Ravel J, etal.Lactobacillus crispatus inhibits growth of Gardnerella vaginalis and Neisseria gonorrhoeae on a porcine vaginal mucosa model. BMC Microbiol. 2015 Dec 9;[J].BMC Microbiol., 2015, 15:276-
|
[39] |
das Neves Selis N, de Oliveira HBM, Le?o HF, etal.Lactiplantibacillus plantarum strains isolated from spontaneously fermented cocoa exhibit potential probiotic properties against Gardnerella vaginalis and Neisseria gonorrhoeae.[J].BMC Microbiol, 2021, 21(1):198-
|
[40] |
N' Guessan Gnaman KC, Bouttier S, Yeo A, etal.Characterization and in vitro evaluation of a vaginal gel containing Lactobacillus crispatus for the prevention of gonorrhea.[J].Int J Pharm., 2020, 588:119733-
|
[41] |
刘栓, 李宜坤, 万丹等.乳铁蛋白生物学功能研究进展[J].动物营养学报, 2020, 32(04):1508-1515
|
[42] |
王楠楠, 蔡婷婷, 朱婉萍.乳铁蛋白抗菌作用研究进展[J].食品科技, 2020, 45(08):233-237
|
[43] |
王淑晨, 于景华, 刘晓辉, 等.乳铁蛋白铁饱和度对其耐热性、抑菌作用及抗氧化性的影响[J].中国乳品工业, 2019, 47(10):29-33
|
[44] |
于淑媛, 冀禹彤, 陈秋艳等.乳酸乳球菌表达重组牛乳铁蛋白肽的抑菌活性分析[J].微生物学报, 2021, 61(02):428-443
|
[45] |
张鹏云, 刘马峰, 程安春.细菌铁离子利用系统与宿主抗感染免疫[J].生命科学研究, 2016, 20(01):82-88
|
[46] |
Valenti P, Rosa L, Capobianco D, etal.Role of Lactobacilli and Lactoferrin in the Mucosal Cervicovaginal Defense.[J].Front Immunol, 2018, 9:376-
|
|
|