目的研究近几年来淋病奈瑟菌(简称淋球菌)对抗生素的敏感性,探讨中西医结合治疗的有效性。方法对我科从2000年1月～2007年6月收治保存的126株淋球菌分别用纸片扩散法和快速药敏测试法进行15种药物的药敏检测,并用头孢曲松合并中药治疗。结果用快速定量药敏检测法测定的最小抑菌浓度(MIC)与用K-B法基本相符。对环丙沙星的耐药率为40%,1.50%的菌株耐大观霉素(MIC≥64μg/ml);所有菌株均对头孢曲松敏感。中西医结合治疗所有病例均获得痊愈。结论头孢曲松药物敏感性无明显变化,6年间未发现耐药菌株;环丙沙星耐药性显著上升。中西医结合在淋病治疗中有效可行。

Objective To monitor antibiotic resistance of Neisseria gonorrhoeae and to test the validity of an integrated traditional and Western medicine therapy regimen. Methods One hundred twenty-six strains of clinically collected Neissena gonorrhoeae were analyzed. A rapid quantitative method of minimum inhibitory concentration (MIC) was used to test 15 anti-microbial agents against 82 strains of Neissena gonorrhoeae, controlled by the Kirby-Bauer, or paper diffusion, method. Patients were treated with ceftriaxone, a third generation cephalosporin antibiotic and traditional medicine. Results There was no difference between the rapid quantitative method and paper diffusion method in detecting antibiotic sensitivity.The antibiotic resistance rate to ciprolloxacin was 75.40% and all strains ( 100%) were sensitive to ceftriaxone. Following the integrated treatment regimen, all patients were cured of their infection. Conclusion The sensitivity of Neisseria gonorrhoeae to ceftriaxone has been steady over the past 6 years, but the antibiotic resistance rate to ciprofloxacin has incresaed. Integrated traditional and Western medicines afforded patients complete recovery from gonorrhea infection.