男性尿道炎尿道多形核白细胞与沙眼衣原体和淋病奈瑟菌感染临床相关性分析

龚匡隆; 尤永燕; 张津萍; 孙厚华; 沙仲; 龚向东

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微生物与感染 ›› 2008, Vol. 3 ›› Issue (2) : 80-83.

论著

男性尿道炎尿道多形核白细胞与沙眼衣原体和淋病奈瑟菌感染临床相关性分析

龚匡隆; 尤永燕; 张津萍; 孙厚华; 沙仲; 龚向东

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Evaluation on the relationship between urethral polymorphonclear leukcyteson infections of Chlaydia trachomatis and Neisseria gonorrhoeae in male patients with utrthritis

GONG Kuang-long; YOU Yong-yan; ZHANG Jin-ping; SUN Huo-hua; SHA Zhong; GONG Xiang-dong

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摘要

目的：沙眼衣原体和淋病奈瑟氏球菌是引起泌尿生殖系统尿道炎疾病常见的致病菌。临床化验一般采用美蓝染色检查男性尿道多形核白细胞或病原微生物阳性可提示尿道炎症状，指导临床的早期治疗。在缺乏临床症状体征和尿道多形核白细胞的情况下，临床的治疗将是不同的。本研究采用美兰染色检查男性尿道炎患者多形核白细胞数量、沙眼衣原体抗原和淋病奈瑟氏球菌培养，评价非淋菌性尿道炎和淋病的临床意义。方法：3,000例性病患者的尿道分泌物进行美兰涂片染色镜检，衣原体抗原检测和淋病奈瑟氏球菌染色镜检和培养。结果：3,000例性病患者中，387例患者（12.9%）沙眼衣原体抗原阳性。在沙眼衣原体患者中，242例（62.5%）≥5个多形核白细胞, 59例（15.2%）为1~4个多形核白细胞,86例（22.2%）为0个多形核白细胞，其中36例患者（9.3%）无症状，141例患者（36.4%）无体征。415例（13.8%）淋病奈瑟氏球菌阳性，在淋病患者中，397例（95.7%）≥5个多形核白细胞, 10例（2.4%）1~4个多形核白细胞, 8例（1.9%）为0个多形核白细胞，其中5例（1.2%）患者无症状， 46例(11.1%)无体征。86例沙眼衣原体和淋病奈瑟氏球菌合并感染的患者中，76例阳性患者≥5个多形核白细胞，5例阳性患者为1~4个多形核白细胞, 5例阳性患者无多形核白细胞。结论：本研究分析了尿道炎患者尿道多形核白细胞，沙眼衣原体和淋球菌感染的相互之间的关系，男性尿道炎患者尿道多形核白细胞数量与沙眼衣原体感染和淋球菌感染存在明显的差异（P<0.001）。86例（22.2%）沙眼衣原体感染和8例（1.2%）淋病患者的尿道中无多形核白细胞。因此,加强临床与实验室诊断可提高男性尿道炎的诊断和控制性病的传播。

Abstract

Objective Chlamydia trchomatis and Neisserria gonorrhoeae are the primary bacterial pathogens causing urethral infection in men.Methlend blue stain is used to detect urethral inflammation, suggestive of infection, in men and guide threapeutic dicisions. In the absence of signs, symptoms or polymorphonuclear leukocyte on methlend blue stain(PMNLs).The tctreatment is deferred on management. Studing relation about Chlamydia-infected,Gonorrhea-infeced and PMNLs who compare their clical characteristics of urethral inflammation in men. Metholds 3,000 were presenting for routine sexually transmitted disease care with uethral PMNLS count, the direct qualitive detection of Chlamydia trachomatis antigen and culture. Results: Among 3,000 eligible men,387(12.0%) had chlamydia and 415(13.8%)had gonorrhea. Among chlamydia-infected men,PMNLS per oil-immersion field were ≥5 in 242(62.5%), 1 to 4 in 59(15.2%),and none in 86(22.2%)，36(9.3%) and 141(36.4%) in men were asympomati or signs at that stage oa their infection. Among gonorrhea-infected, PMNs per oil-immersion field were ≥5 in 397(95.7%), 1 to 4 in 10(2.4%), none in 8(1.9%), 5(1.2%) and 46(11.1%) in men were asympomati or signs at that stage oa their infection. And an additional 86 were coinfeced with both organisms. PMNLs were≥5 in 76,1 to 4 in 5,none in 5. Conclusions:The paper used to analyze the ralationship of urethral inflammation PMNs,Chlamydia trachomatis and Neisseria gonorrhoeae infetion.The pations of chlamydia、gonorrhea and PMNLs in men infected have obvious difference(P<0.001). 86(22.2%) of chlamydial and 8(1.2%)of gonococcal infection had no evidence of PMNLs. It is strenuous that both of clical and testing teehnicality is important to increase dignosis for urthral inflammation in men and control sexually transmitted disease.

导出引用

龚匡隆; 尤永燕; 张津萍; 孙厚华; 沙仲; 龚向东. 男性尿道炎尿道多形核白细胞与沙眼衣原体和淋病奈瑟菌感染临床相关性分析
[J]. 微生物与感染. 2008, 3(2): 80-83

GONG Kuang-long; YOU Yong-yan; ZHANG Jin-ping; SUN Huo-hua; SHA Zhong; GONG Xiang-dong. Evaluation on the relationship between urethral polymorphonclear leukcyteson infections of Chlaydia trachomatis and Neisseria gonorrhoeae in male patients with utrthritis[J]. Journal of Microbes and Infections. 2008, 3(2): 80-83