摘要
目的 了解上海地区≤5岁的患急性稀水样便腹泻患儿中轮状病毒感染及星状病毒感染的流行情况及其临床特征。方法 留取2006年6月~2007年3月复旦大学附属儿科医院门诊、住院及医院内感染腹泻患儿的部分粪便标本，应用免疫层析胶体金法检测轮状病毒。排除轮状病毒感染后，应用酶联免疫吸附试验(ELISA)检测星状病毒。本实验主要研究对象为年龄≤5岁，病程≤2周，大便培养无条件致病菌生长患儿。结果 共收集724例急性腹泻粪便标本，年龄≤5岁人群轮状病毒阳性检出率42.5%，约85%患儿年龄≤2岁；病例全年均有发生，发病高峰主要集中在2006年12月~2007年1月。共240例急性腹泻轮状病毒阴性粪便标本中，年龄≤5岁人群星状病毒阳性检出率11.6%，53.6%患儿年龄≤2岁；观测期间病例散发，发病高峰主要集中在2006年10月~2007年1月。结论 轮状病毒是上海地区婴幼儿病毒性腹泻的重要病原，部分患儿伴肠道外损伤。星状病毒是上海地区婴幼儿病毒性腹泻的又一重要病原。
Abstract
Objective To investigate the epidemiology, clinical characteristics, presence of extra-intestinal injury and the direct costs resulting from diarrhea caused by rotavirus and astrovirus infection in children below the age of 5 years in Shanghai. Methods Stool specimens saved from inpatients and outpatients of the Fudan University Children’s Hospital during the period June 2006 to March 2007 were analysed. Initially, the presence of rotavirus was detected using the colloidal gold immunochromatographic assay. Specimens negative for rotavirus were then tested for astrovirus using emzyme-linked immunosorbent assay (ELISA). The target population in this study was children below the age of five, with ≤ 2 weeks of duration of diarrhea, which were negative for bacterial culture. Results A total of 724 stool specimens (5 years old or younger) were collected. Out of 724 samples, 42.5% were positive for rotavirus, of which 85% were from patients of two years old or younger. Cases were distributed throughout the year peaking in December 2006—January 2007. As an account of the economic burden this type of illness places on families, 50% of community-acquired inpatients have hospital bills ranging from RMB 1 473.7—4 029.6 (25th percentile to 75th percentile) and 50% of hospital-acquired inpatients have hospital bills ranging from RMB 3 096.8—1 0552.3 (25th percentile to 75th percentile). Of 276 stool specimens negative for rotavirus (age 5 years or younger), astrovirus was detected in 11.6%, of which 53.6% were from patients of two years old or youger. Cases were distributed all through the year, with a peak from October 2006 to January 2007. Conclusion Both rotavirus and astrovirus are important pathogens which cause viral gastroenteritis in young children in Shanghai.
关键词
星状病毒 /
腹泻 /
儿童
Key words
Rotavirus /
Astrovirus /
Diarrhea /
Children
潘以韵;黄瑛;朱启镕.
上海部分地区小于5岁儿童轮状病毒及星状病毒性腹泻的临床分析 [J]. 微生物与感染. 2008, 3(3): 138-142
PAN Yi-yun; HUANG Ying; ZHU Qi-rong.
Clinical analysis of diarrhea as a result of rotavirus and astravirus infection in children below the age of 5 years in Shanghai[J]. Journal of Microbes and Infections. 2008, 3(3): 138-142
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