溶瘤病毒与癌症治疗

侯剑刚; 丁强

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微生物与感染 ›› 2009, Vol. 4 ›› Issue (1) : 35-39.

综述

溶瘤病毒与癌症治疗

侯剑刚；丁强

作者信息 +

Oncolytic viruses for cancer treatment

HOU Jian-Gang；DING Qiang

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文章历史 +

摘要

近几年溶瘤病毒的研究有很大进展。病毒的感染和增殖导致癌细胞死亡, 并诱发宿主抗肿瘤免疫反应而进一步清除癌细胞。对癌细胞特异性的靶分子或信号通路以及肿瘤微环境的研究, 发现了很多溶瘤病毒。本文就溶瘤病毒的原理、历史、种类、安全性、杀伤效率以及疗效等进行综述。

Abstract

Tremendous advances have been made in developing oncolytic viruses in the last few years. Viral infection and amplification eventually induce cancer cells into cell death pathways and elicit host antitumor immune responses. Specifically targeted molecules or signaling pathways in cancer cells or in the tumor microenvironment have been studied and a variety of oncolytic viruses such as adenovirus, herpes simplex virus, poxvirus, measles virus, Newcastle disease virus and influenza virus have been identified. In this review, the characteristics of oncolytic viruses for cancer therapy are discussed.