本文旨在探讨2009 甲型流行性感冒( 流感) 病毒(H1N1) 感染者的常规免疫学指标与健康人的差异。 采用流式细胞术检测32 名甲型H1N1 感染者外周血不同T 细胞亚群, 同时进行血清特定蛋白检测及血细胞 计数。结果显示, 与健康者相比, 甲型H1N1 感染者外周血CD3⁺ 、CD3⁺ CD4⁺ 、CD3⁺ CD8⁺ T 细胞( cells/μl) 显著降低, 血清补体成分C3、C4( g/L) 及C反应蛋白均值( mg/L) 显著升高, 血小板、白细胞、淋巴细胞与嗜酸性细胞显著降低, 单核细胞显著升高。结果提示, 甲型H1N1 感染者的常规免疫学指标出现异常发展趋势。

The paper aimed to investigate the differences in immunological evaluations between influenza type A H1N1 virus-infected patients and uninfected individuals. T-cell subtypes in peripheral blood from 32 H1N1-infected patients were quantified using flow cytometry. Specific protein markers in serum were determined and blood cells were counted. The results showed thatmean counts of CD3⁺ , CD3⁺ CD4⁺ , and CD3⁺ CD8⁺ T cells in peripheral blood of H1N1-infected patients were significantly reduced compared with those in uninfected individuals whereas serum complement components ( C3 and C4) and C-reaction protein were significantly increased in H1N1-infected patients. Furthermore, platelets, leukocytes, lymphocytes, and eosinophilic cells were significantly decreased, while monocytes were significantly increased in this population. It is indicated that routine immunological evaluation has
clinical significance in H1N1-infected patients.