目前已证实, 格特隐球菌病可暴发流行。近10 年来, 在加拿大温哥华岛暴发的格特隐球菌病发病率显著高于其他地区, 且大部分感染者免疫力正常, 该致病菌已蔓延至周边地区。本文就格特隐球菌病暴发流行机制, 包括致病菌的分子流行病学分析、可能来源、毒力分析和播散机制进行综述。

Cryptococcus gattii infection has the potential to cause a significant outbreak. Over the past 10 years, the incidence of Cryptococcus gattii infection in Vancouver Island, Canada has been significantly higher than that observed in other areas throughout the world. During this outbreak, most patients were immunocompetent. Cryptococcus gattii has been reported to disperse to adjacent areas. In this paper , the mechanisms responsible for outbreaks of Cryptococcus gattii infection, including molecular typing analysis,possible origin, virulence factors, and dispersal mechanisms of the pathogen are reviewed.