肠道病毒7l 型( EV71) 是导致手足口病的主要病原体之一, 常引起多种与神经系统相关的严重疾病。自1969 年首次分离以来, 其感染已在世界范围内引起数次暴发与流行, 尤其是近几年在亚太地区呈上升趋势, 且出现越来越严重的神经系统症状。目前, 对于EV71 病毒结构及其所致严重神经系统症状的机制, 以及疫苗的开发等已进行了大量和深入的研究。

Enterovirus type 71 ( EV71) is one of the major etiological agents of hand, foot and mouth disease (HFMD), which often causes severe neurological complications. Since EV71 was first isolated in 1969, several epidemics of EV71 infection have broken out around the world, particularly in the Asia-Pacific region with high incidence of neurological involvement in recent years. Many researches have been conducted to investigate the structure of EV71, the mechanisms that may cause neurological complications, and the opportunities for vaccine development.