细胞自噬在固有免疫和获得性免疫中发挥重要作用。自噬一方面通过溶酶体清除胞质内微生物, 发挥天然抗感染免疫作用; 另一方面可通过调节抗原加工、呈递, 在获得性免疫反应中发挥效应。自噬除可参与并增强组织相容性复合物( MHC) Ⅱ类分子的抗原呈递外, 在经典和非经典MHCⅠ类抗原呈递中也发挥辅助作用。

Autophagy plays an important role in the innate and adaptive i mmune . On one hand, it acts as an innate i mmune response when eli minating microbes in cells vialysosome degradati on ; on the other hand, it acts effectively in adaptive i mmunity by regulating antigen processing and presentation. Autophagy is not only involvedin and enhances major histocompatibility complex ( MHC) II antigen presentation , but it also assists with classic and nonclassic MHCI antigen presentati on .