通过检测梅毒患者经正规治疗前后血清抗体变化，评价梅毒实验室各种血清学试验方法对梅毒的诊断和随访的临床意义。 本文采用暗视野显微镜检查梅毒螺旋体、RPR、TPPA和TP-IgM ELISA等试验方法对135例梅毒患者正规治疗前后的血清进行检测。结果显示，治疗前，一期（硬下疳）梅毒血清试验的敏感性分别为83.3%、91.7%和91.7%，暗视野检查全部阳性；二期梅毒血清试验的敏感性均为100.0%；早期潜伏梅毒血清试验的敏感性分别为88.9%、100.0%和88.9%，说明了三种梅毒血清学试验对未治疗的梅毒患者的诊断中， TPPA试验的灵敏度最高。正规治疗12个月后，一期硬下疳梅毒患者RPR血清试验与TP-IgM-ELISA试验结果均为阴性；二期梅毒血清试验阴性分别为64.5%和67.7%，基本一致；早期潜伏梅毒血清试验阴性均为38.9%。即对正规治疗后的梅毒患者的随访，TP-IgM-ELISA试验阴性，RPR试验基本上也阴性，由于TP-IgM-ELISA试验的试剂昂贵，可以用RPR代替。综上所述，TPPA和RPR试验用于梅毒的常规诊断和随访仍是最好的试验方法。

Approach to syphilis antibodys of stnadurd treated at  previousli untreated and after treatment syphilis change with syphilis serological  tests. Evaluation value of syphilis were used by syphilis serological test detection in the diagnosis of the clinie. Dark field microscopy, RPR, TPPA and TP-IgM-ELISA tests were detected by 135 previously untreated and after completion  treatment of syphilis. 135  previously untreated patients: In 24 cases of primary chancre syphilis,the dark field microscopy  were positive, RPR and TPPA and  TP-IgM-ELISA  of serological test were positive in 83.3%, 91.7% and 91.7% of, respectively. All the serological tests were positive in 93 patients with secondary syphilis. In 18 early latent syphilis, the serological tests were positive 88.9%, 100.0% and 88.9%,respectivedy. 12  months after completion of treatment in RPR and TP-IgM-ELISA test, 20 and 22 primary syphilis were negative in 100.0%. 93 of secondary syphilis were negative in 64.5% and 67.7%, respectively. 18 early latent syphilis were negative in 38.9% in RPR and TP-IgM-ELISA test, respectively. These results reflect the associations of treponemal serological test, when RPR and TP-IgM-ELISA tests is positive, TPPA test is positive well in  previously untreated syphilis,which the TPPA is higher sensitivity method to detect aerly latent syphilis. Twelve months after completion treatment of syphlis , when TP-IgM-ELISA test is negative， RPR test is negative basically. It is indicated that RPR and TPPA test are the best of  serological test of syphilis with clinical  routine diagnosis and obaservation.