人乳头瘤病毒感染是宫颈癌发生的重要始动原因，从HPV感染到宫颈癌发生，需要许多共刺激因子的参与。这些共刺激因子均可引起宫颈局部一氧化氮浓度的增高。而一氧化氮既可影响HPV的转录和翻译，又在肿瘤发生过程中具有重要调节作用。深入研究一氧化氮、人乳头瘤病毒感染及宫颈癌之间的关系，可为宫颈癌的防治提供新的重要理论基础和药物研制实验平台，通过使用一氧化氮合酶抑制剂降低宫颈局部NO浓度将为全面有效防治宫颈癌带来新的希望。

Human papillomavirus(HPV) infection is an important causes of cervical cancer. From HPV infection to carcinogenesis , a number of co-factors are required. All the co-factors can cause the increase of local concentration of nitric oxide. The nitric oxide can affect the transcription and translation of HPV, but also play an important regulatory role in carcinogenesis. Clarifying the relationship of nitric oxide, human papillomavirus infection and cervical cancer is very important to develop experimental drug platform.