病原体在长期进化中形成多种策略以有利于自身增殖，进而导致多种疾病。这些策略包括干扰宿主免疫反应、调控细胞周期与凋亡等。近年来，人们越来越关注病原体通过干扰宿主细胞周期致病的机制，了解病原体-宿主之间的相互作用。本文综述了病原体引起宿主细胞周期停滞在不同时期的机制，特别是一些细菌分泌毒力因子引起宿主细胞周期紊乱及其致病作用。深入研究病原体对宿主细胞周期的影响及方式，可进一步揭示其致病性，对疾病治疗及新药研制具有潜在价值。

Because of evolution for millions of years, microbial pathogens have developed specific strategies to manipulate host cell functions for their own benefits. Many of these measures involve interference with host immune responses, regulation of host cell cycle or induction of programmed cell death. During the past few decades, there has been remarkable progress in the understanding of microbial pathogens interfering with the host cell cycle and its putative role in diseases. Here, we review some pathogenic microorganisms arresting host cell cycle at different phages and their mechanisms, especially some pathogenic bacteria delivering effector protein into host cells to modulate the host function. Therefore, further research on the mechanisms of host cell cycle manipulated by pathogenic microorganisms can serve as a clue to understand host-pathogen interaction and its pathogenesis, which may be useful for the development of new drug targets and (or) vaccine candidates.