人巨细胞病毒(HCMV) 可感染肿瘤细胞，并增加肿瘤恶性程度。最近一些研究者对恶性胶质瘤患者的临床研究发现， HCMV 感染的肿瘤细胞数量与肿瘤的恶性程度有关。HCMV 通过影响细胞周期进展、阻断受感染细胞凋亡、影响肿瘤细胞恶性行为等发挥肿瘤调节作用。探讨HCMV 肿瘤调节作用的具体机制，对将HCMV 作为肿瘤治疗的个靶目标拓展肿瘤预防和治疗的新思路有重要意义。本文就HCMV 诱导肿瘤调节作用分子机制的研究现状作一综述。

Studies have confirmed that human cytomegalovirus (HCMV) infection may be associated with certain malignant tumors. Oncomodulation suggests that HCMV can infect tumor cells and influence their malignancy and in this particular case increase it. Some clinical studies show that the number of HCMV infected tumor cells has been implicated in the degree of tumor malignancy in patients with glioblastoma, suggesting that HCMV may exert oncostimulatory effects. Influencing the cell cycle, blocking apoptosis of the infected cells, influencing the malignant behavior of tumor cells, and so on, may contribute to the oncomodulatory effects of HCMV. An investigation into the molecular mechanisms of such oncomodulatory effects of HCMV will be significant to expand the prevention and treatment of cancer.