白假丝酵母（又称白念珠菌）是人体重要的条件致病真菌。在正常人体中，白假丝酵母是一种无害共生真菌；在免疫力低下人群中，白假丝酵母可引起假丝酵母病，轻者可导致黏膜感染，重者可发展为系统疾病，直至危及生命。白假丝酵母从酵母态至菌丝态的形态转变是极其重要的致病因素之一。BDSF是小分子短链脂肪酸，由Burkholderia cenocepacia分泌产生。酵母态白假丝酵母，在BDSF≥30 μmol/L时因菌丝生长受强烈抑制，无法由酵母相向菌丝相转变。而菌丝相白假丝酵母，当BDSF在30 μmol/L和60 μmol/L时，菌丝进一步生长并产生分支，但随菌丝分支生长，新生的分支菌丝不断转变为酵母态；当BDSF增加至120 μmol/L时，菌丝生长和分支状况几乎完全受抑制。由此可见，BDSF不仅强烈抑制菌丝生长，还可促使新生的菌丝态向酵母态转化。

Candida albicans (C. albicans) is a very important opportunistic human pathogenic fungus. It is a harmless symbiotic fungus that inhabits various niches of healthy individuals. However, in the immunocompromised population, C. albicans can cause infection and even C. albicans candidiasis, which can range from superficial mucous membrane infection to life-threatening systemic disease. The state change of hypha from yeast form is a extremely important pathogenic factor. BDSF is a short-chain fatty acid molecule, secreted by the Burkholderia cenocepacia. When BDSF was added to yeast state at 30 μmol/L, it strongly inhibited the mycelial growth of C. albicans, so that yeast C. albicans could not be achieved to the change of the hyphal state; when at the concentration of 30 μmol/L and 60 μmol/L, BDSF did not inhibit the further growth and branching hyphae, but with the growth of mycelium branches the new-born branches of the mycelium were constantly changed into yeast state; when at the concentration of 120 μmol/L, BDSF almost completely inhibited the mycelial growth and branching. It’s suggested that BDSF not only strongly inhibits the hypha growth from yeast state but also forcefully promotes the transition from new-born hypha to yeast state.