铜绿假单胞菌是一种常见的医院获得性感染条件致病菌。随着超广谱抗菌药物的广泛和不合理使用，铜绿假单胞菌对日-内航肢类抗菌药物的耐药性逐渐增强，给医院抗感染治疗带来极大困难。铜绿假单胞菌对β-内航肢类抗菌药物的耐药机制相当复杂，具有天然耐药和获得性耐药特点，本文对其耐药及传播机制的研究进展进行综述。

Pseudomonas aeruginosa is a conditional pathogen and the leading species isolated from hospitalacquired infections. With the increasing and unrational usage of antibiotics , the resistance of Pseudomonas aeruginosa to β-lactam antibiotics has gradually increased, and then the anti-infection therapy in hospitals becomes even more difficult. The resistance mechanism of Pseudomonas aeruginosa to β-lactam antibiotics is complex, including natural and acquired drug-resistance. In this paper, the recent researches on mechanisms of resistance to β-lactam antibiotics and transmission of Pseudomonas aeruginosa are reviewed.