摘要：近70年来，由于抗生素的广泛使用，金黄色葡萄球菌的耐药菌不断出现。在美国，从1999年到2005年，因感染MRSA而入院的患者增加了一倍多，其中被诊断为败血症的患者增加了81.2%。因此，寻找控制耐药菌的新对策显得十分迫切。目前有望替代抗生素的控菌手段有抗菌肽、噬菌体等。其中，噬菌体的发现早于抗生素，后因抗生素的普及而被忽视。如今，耐药菌株的流行使噬菌体治疗再次受到关注。本文就应用噬菌体及其裂解酶控制金黄色葡萄球菌的研究进展进行详细介绍。

Abstract: In recent 70 years, the wide use of antibiotics leads to the increasing drug-resistance bacteria. In America, from 1999 through 2005, estimated MRSA-related hospitalizations more than doubled, and MRSA-related hospitalizations with a diagnosis code for septicemia increased 81.2%. Therefore, it is urgent to seek novel countermeasures, which include antibacterial peptide and bacteriophage at present, to control drug-resistance bacteria. Despite bacteriophage was discovered earlier, it was ignored owing to antibiotic popularity. But now, bacteriophages come back into view as a result of increasing drug-resistance bacteria. Here, we introduce the research progress on bacteriophage and lysin control of Staphylococcus aureus.