全血γ干扰素释放试验在儿童和成人中的结核病诊断价值

鲍磊1,李涛2,卢水华2

微生物与感染 ›› 2014, Vol. 9 ›› Issue (1) : 21-27.

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微生物与感染 ›› 2014, Vol. 9 ›› Issue (1) : 21-27.
论著

全血γ干扰素释放试验在儿童和成人中的结核病诊断价值

  • 鲍磊1,李涛2,卢水华2
作者信息 +

Evaluation of a whole-blood interferon γ release assay for the diagnosis of tuberculosis in children and adults

  • BAO Lei1, LI Tao2, LU Shui-Hua2
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摘要

为研究全血γ干扰素释放试验(QuantiFERON TB Gold In-Tube test, QFT-GIT)在中国(属结核病高发、BCG高接种地区)成人和儿童中的结核病诊断价值,入组临床怀疑结核病的儿童和成人患者各60例,进行QFT-GIT检测,并收集临床资料作诊断分类。结果显示,在儿童中QFT-GIT诊断结核病的灵敏度为83.87%、特异度为92%、阳性预测值(PPV)为92.86%、阴性预测值(NPV)为82.14%;在成人中诊断结核病的灵敏度为78.57%、特异度为84.62%、PPV为84.62%、NPV为78.57%。结果证实QFT-GIT对结核病具有良好的诊断价值,尤其在儿童中的诊断价值高于成人。

Abstract

In order to evaluate the diagnostic value of the whole-blood interferon γ release assay (QuantiFERON TB Gold In-Tube test, QFT-GIT) in diagnosis of tuberculosis in children and adults in China (with a high rate of bacillus Calmette-Guérin vaccination and a high incidence of tuberculosis), 60 children and 60 adults with suspected tuberculosis were recruited for QFT-GIT test and clinical information collection. The results showed that among children, the sensitivity of QFT-GIT test was 83.87%, the specificity was 92%, positive predict value (PPV) was 92.86%, and negative predict value (NPV) was 82.14%. While among adults, the sensitivity of QFT-GIT test was 78.57%, the specificity was 84.62%, PPV was 84.62%, and NPV was 78.57%. Here comes a conclusion that QFT-GIT is of great value in diagnosis of tuberculosis, especially among children.

关键词

酶联免疫吸附法;儿童;成人;结核分枝杆菌;&gamma / 干扰素释放试验

Key words

Enzyme-linked immunosorbent assay / Child / Adult / Mycobacterium tuberculosis / Interferon &gamma / release assay

引用本文

导出引用
鲍磊1,李涛2,卢水华2. 全血γ干扰素释放试验在儿童和成人中的结核病诊断价值[J]. 微生物与感染. 2014, 9(1): 21-27
BAO Lei1, LI Tao2, LU Shui-Hua2. Evaluation of a whole-blood interferon γ release assay for the diagnosis of tuberculosis in children and adults[J]. Journal of Microbes and Infections. 2014, 9(1): 21-27

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