近年来，医院获得性感染中革兰阳性菌感染呈上升趋势，而耐甲氧西林金黄色葡萄球菌（MRSA）已成为医院感染中的常见病原菌，具有多重耐药特征，给临床治疗带来困难。利奈唑胺是第1个应用于临床的新型唑烷酮类抗生素，对葡萄球菌、链球菌、肠球菌等耐药革兰阳性菌有广谱抗菌作用。本文报道1例革兰阳性球菌所致医院获得性肺炎患者，予利奈唑胺治疗后胸部CT示炎症明显吸收，血常规恢复正常，未再发热，病情好转出院。结果显示，利奈唑胺能有效治疗耐药革兰阳性菌所致医院获得性肺炎。

Recently, hospital-acquired pneumonia with Gram-positive bacterial infection has risen. Methicillin-resistant Staphylococcus aureus (MRSA) has become a major pathogen of iatrogenic infection, which is characterized by multi-drug resistance and difficulties in clinic treatment. Linezolid is the first new type of oxazolidinone antibiotic used in clinic，with broad-spectrum antibacterial activity against staphylococci，streptococci，and enterococci. To evaluate the efficacy and safety of linezolid, a patient with hospital-acquired pneumonia caused by Gram-positive cocci infection was reported in the present paper. The results showed that linezolid was effective．