迄今为止，获得性免疫缺陷综合征（AIDS）在全球依然是非常严重的传染病，还没有彻底治愈的疗法。抗病毒疗法可抑制人类免疫缺陷病毒（HIV）复制，但不能彻底清除潜藏在人基因组中的HIV基因组序列。最近，基因组编辑技术如锌指核酸酶（ZFN）技术、类转录激活因子效应物核酸酶（TALEN）技术和成簇的规律间隔的短回文重复序列及其相关蛋白（CRISPR-Cas）技术被发现可成功破坏整合在人基因组中的HIV基因组序列，并成功诱导HIV辅助受体C-C趋化因子受体5（CCR5）缺失突变，而这种突变可抵抗HIV进入细胞。基因组编辑技术的成功应用将为治愈AIDS带来曙光。

Acquired immunodeficiency syndrome (AIDS), still a serious infectious disease, causes global epidemic and remains incurable until now. The current available antiretroviral therapy successfully inhibits human immunodeficiency virus (HIV) replication, but can not eradicate the genome-integrated HIV. Recently, genome editing techniques, such as zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas) (CRISPR-Cas system), have been found to successfully disrupt the integrated HIV-1 genes. Furthermore, genome editing techniques also have successfully induced C-C chemokine receptor type 5 (CCR5) ?32 mutation, a mutation of HIV entry coreceptor CCR5 that is resistant to HIV infection. Therefore, genome editing techniques bring the glimmers of success in eradication of HIV in human bodies.