肠道病毒71型(enterovirus 71，EV71)为小RNA病毒科肠道病毒属成员，是引起手足口病的主要病原体之一。EV71流行广泛，其感染可引发中枢神经系统疾病，并造成重症手足口病，给公共卫生安全带来极大挑战。EV71的致病机制与病毒和宿主天然免疫系统的相互作用关系密切，涉及病毒逃逸干扰素反应、病毒抑制核因子κB(nuclear factor κB，NF-­κB)信号通路及病毒与天然免疫细胞相互作用等多个环节。本文就近年来EV71与宿主天然免疫系统相互作用的研究进展进行综述。

Enterovirus 71 (EV71) is a pathogen for hand, foot and mouth disease (HFMD), and its prevalence is a great challenge to public health. Pathogenesis of EV71 is closely related to a panel of host innate immune responses, such as escape of interferon response, suppression of nuclear factor κB (NF­-κB) signaling pathway and interactions between virus and innate immune cells. This review focuses on the new progress on interactions between EV71 and host innate immunity.