成簇的规律间隔的短回文重复序列及其相关蛋白9〔clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9)，CRISPR/Cas9〕是一种新兴的基因编辑技术，与以前的三大基因编辑技术——归巢核酸内切酶、锌指核酸酶和转录激活因子样效应物核酸酶技术相比，其在靶向特异性、操作简便性、治疗彻底性、应用广泛性等方面具有更大的优势和发展潜力。艾滋病、乙型肝炎、疟疾等感染性疾病的治疗一直是医学上的重大难题，科学家正努力尝试利用CRISPR/Cas9技术解决这些医学难题。本文主要综述了CRISPR/Cas9技术在这些感染性疾病中应用的研究进展。

The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9)(CRISPR/Cas9) technology is a new gene editing technique. Compared with the previous gene editing techniques, such as homing endonuclease technology, zinc finger nuclease technology and transcription activator-like effector nuclease technology, it has greater advantages in target specificity, operation simplicity, treatment completeness and broad applications. Hepatitis B, acquired immunodeficiency syndrome (AIDS), malaria and other infectious diseases have been the major problems in clinic. Scientists are trying to use CRISPR/Cas9 technology to solve these medical problems. This article mainly summarizes the progress on CRISPR/Cas9 technology applied in infectious diseases.