本文报道广西医科大学第一附属医院皮肤性病科收治的马尔尼菲蓝状菌病致溶骨性损害合并Sweet样皮疹1例。免疫力正常人群较少患马尔尼菲蓝状菌病。本例患者既往体健，起初合并融骨性损害，在两性霉素B、伊曲康唑治疗过程中逐渐出现Sweet样皮疹。患者经两性霉素B、伊曲康唑、激素等治疗后，病情逐渐好转。

Talaromyces marneffei (T. marneffei) infection in healthy subjects is rare. A case of osteolysis plus Sweet’s syndrome like lesions associated with T. marneffei infection was presented. The patient was human immunodeficiency virus (HIV) negative. The osteolysis caused by T. marneffei was detected first and Sweet’s syndrome like lesions were developed during antifungal treatment with amphotericin B and itraconazole. After the treatment with amphotericin B, itraconazole and glucocorticoids, the patient’s condition gradually improved.