艾滋病痴呆综合征(acquired immunodeficiency syndrome dementia complex, ADC)是由人类免疫缺陷病毒(human immunodeficiency virus，HIV)侵犯中枢神经系统，造成患者意识、行为和运动能力改变为主要临床表现的综合征。约50%的HIV感染者表现出不同形式的认知功能损伤。ADC的发病机制尚未完全阐明，诊断也无明确的病理和生化指标。目前，蛋白质组学技术以其高灵敏度和高通量的特点广泛应用于传染病研究。本文综述了近年来ADC蛋白质组学研究领域的进展，包括ADC蛋白质组学研究所用样品、蛋白质组学技术及其在ADC研究中的应用，为ADC的诊断和发病机制研究提供新思路。

Acquired immunodeficiency syndrome dementia complex (ADC) is a human immunodeficiency virus (HIV)-related brain syndrome, which is caused by HIV invading the central nervous system. ADC may have impacts on patient’s consciousness, behavior and exercise ability. Although cognitive deficit is associated with around 50% of HIV-infected people, the pathogenesis of ADC has not been clarified, and the diagnosis is still unclear. Proteomic technology can provide new clues for the diagnosis, pathogenesis, prevention and treatment of ADC due to its high sensitivity and high throughput capacity. In this paper, the progress of proteomic studies on ADC in the last 5 years is reviewed.