【摘要】目的：通过总结约翰逊不动杆菌（Acinetobocter johnsonii）致新生儿败血症的临床特点及治疗转归，探讨新生儿约翰逊不动杆菌感染的诊断和治疗措施。方法：回顾性分析2例新生儿约翰逊不动杆菌感染败血症的临床详细资料，并查阅相关文献进行分析。结果：2例胎龄分别为26+5周和34周，出生体重1050 g和1800 g,分别在生后第21天和第23天发生败血症，血培养证实为约翰逊不动杆菌，经抗感染、呼吸支持等治疗后分别住院40天和36天顺利出院。结论：约翰逊不动杆菌是一种少见人类感染病原体，确诊依靠血培养，而基质辅助激光解吸/电离飞行时间质谱有助于约翰逊不动杆菌鉴定，抗菌药物的选择应尽量根据药敏检测结果及MIC值、患儿本身的生理状态进行。
Abstract
【Abstract】Objective: To investigate the diagnosis and treatment of neonatal Acinetobocter johnsonii (AJ) infection by summarizing the clinical characteristics and treatment outcome of neonatal sepsis caused by AJ. Method: The clinical details of 2 cases of neonatal AJ sepsis were retrospectively analyzed, and the relevant literature was consulted for analysis. Result: Two cases with gestational age of 26+5 weeks and 34 weeks, birth weight of 1050 g and 1800 g, developed sepsis on postnatal days 21 and 23, separately, which were confirmed to have AJ infection by blood culture and were discharged uneventfully after 40 and 36 days of hospitalization after treatment. Conclusion: AJ is a rare human infectious pathogen. The diagnosis depends on blood culture. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry can help AJ identification. The selection of antibacterial drugs should be based on the results of drug susceptibility testing and MIC values, as well as the physiological state of the children themselves.
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