[1]Andersen P, Andersen AB, Sorensen AL, Nagai S.Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice[J].J Immunol, 1995, 154(7):3359-3372 [2]Harboe M, Oettinger T, Wiker HG, Rosenkrands I, Andersen P.Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG[J].Infect Immun, 1996, 64(1):16-22 [3]Abdallah AM, Pittius NCGV, Champion DG, Cox J, Luirink J, Vandenbroucke-Grauls CMJE, Appelmelk BJ, Bitter W.Type VII secretion--mycobacteria show the way[J].Nat Rev Microbiol, 2007, 5(11):883-891 [4]Newton-Foot M, Warren RM, Sampson SL, Van Helden PD, Claudius GVPN.The plasmid-mediated evolution of the mycobacterial ESX (Type VII) secretion systems[J].BMC Evol Bio, 2016, 16(1):62-62 [5]Bowman L, Palmer T.The Type VII Secretion System of Staphylococcus[J].Annu Rev Microbiol, 2021, 75(1):471-494 [6]Anes E, Pires D, Mandal M, Azevedo-Pereira JM.ESAT-6 a Major Virulence Factor of Mycobacterium tuberculosis[J].Biomolecules, 2023, 13(6):968-968 [7]Bao Y, Wang L, Sun J.A Small Protein but with Diverse Roles: A Review of EsxA in Mycobacterium-Host Interaction[J].Cells, 2021, 10(7):1645-1645 [8]Sun J, Champion PA, Bigi F.Editorial: Cellular and Molecular Mechanisms of Mycobacterium tuberculosis Virulence[J].Front Cell Infect Microbiol, 2019, 9(1):331-331 [9]Sengupta N, Padmanaban S, Dutta S.Cryo-EM reveals the membrane-binding phenomenon of EspB,a virulence factor of the mycobacterial type VII secretion system[J].J Biol Chem, 2023, 299(4):104589-104589 [10]Lai LY, Lin TL, Chen YY, Hsieh PF, Wang JT.Role of the Mycobacterium marinum ESX-1 Secretion System in Sliding Motility and Biofilm Formation[J].Front Microbiol, 2018, 9(1):1160-1160 [11]Wang Q, Boshoff HIM, Harrison JR, Ray PC, Green SR, Wyatt PG, Barry CE 3rd.PEPPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis[J].Science, 2020, 367(6482):1147-1151 [12]樊博, 王巍, 程小星.结核分枝杆菌和家族研究进展[J].国际呼吸杂志, 2011, 31(6):454-457 [13]Burts ML, Williams WA, DeBord K, Missiakas DM.EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections[J].Proc Natl Acad Sci USA, 2005, 102(4):1169-1174 [14]Cao Z, Casabona MG, Kneuper H, Chalmers JD, Palmer T.The type VII secretion system of Staphylococcus aureus secretes a nuclease toxin that targets competitor bacteria[J].Nat Microbiol, 2016, 2(1):16183-16183 [15]Bagnoli F, Fontana MR, Soldaini E, Mishra RP, Fiaschi L, Cartocci E, Nardi-Dei V, Ruggiero P, Nosari S, De Falco MG, Lofano G, Marchi S, Galletti B, Mariotti P, Bacconi M, Torre A, Maccari S, Scarselli M, Rinaudo CD, Inoshima N, Savino S, Mori E, Rossi-Paccani S, Baudner B, Pallaoro M, Swennen E, Petracca R, Brettoni C, Liberatori S, Norais N, Monaci E, Bubeck Wardenburg J, Schneewind O, O' Hagan DT, Valiante NM, Bensi G, Bertholet S, De Gregorio E, Rappuoli R, Grandi G.Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus[J].Proc Natl Acad Sci U S A, 2015, 112(12):3680-3685 [16]Kneuper H, Cao ZP, Twomey KB, Zoltner M, J?ger F, Cargill JS, Chalmers J, van der Kooi-Pol MM, van Dijl JM, Ryan RP, Hunter WN, Palmer T.Heterogeneity in ess transcriptional organization and variable contribution of the EssType VII protein secretion system to virulence across closely related Staphylocccus aureus strains[J].Mol Microbiol, 2015, 93(5):928-943 [17]Klein TA, Pazos M, Surette MG, Vollmer W, Whitney JC.Molecular Basis for Immunity Protein Recognition of a Type VII Secretion System Exported Antibacterial Toxin[J].J Mol Biol, 2018, 430(21):4344-4358 [18]Garrett SR, Mietrach N, Deme J, Bitzer A, Yang Y, Ulhuq FR, Kretschmer D, Heilbronner S, Smith TK, Lea SM, Palmer T.A type VII-secreted lipase toxin with reverse domain arrangement[J].Nat Commun, 2023, 14(1):8438-8438 [19]Ulhuq FR, Gomes MC, Duggan GM, Guo M, Mendonca C, Buchanan G, Chalmers JD, Cao Z, Kneuper H, Murdoch S, Thomson S, Strahl H, Trost M, Mostowy S, Palmer T.A membrane-depolarizing toxin substrate of the Staphylococcus aureus type VII secretion system mediates intraspecies competition[J].Proc Natl Acad Sci U S A, 2020, 117(34):20836-20847 [20]Cao Z, Casabona MG, Kneuper H, Chalmers JD, Palmer T.The type VII secretion system of Staphylococcus aureus secretes a nuclease toxin that targets competitor bacteria[J].Nat Microbiol, 2016, 2(1):16183-16183 [21]Wang S, Zhou K, Yang X, Zhang B, Zhao Y, Xiao Y, Yang X, Yang H, Guddat LW, Li J, Rao Z.Structural insights into substrate recognition by the type VII secretion system[J].Protein Cell, 2020, 11(2):124-137 [22]Daleke MH, Ummels R, Bawono P, Heringa J, Vandenbroucke-Grauls CM, Luirink J, Bitter W.General secretion signal for the mycobacterial type VII secretion pathway[J].Proc Natl Acad Sci U S A, 2012, 109(28):11342-11347 [23]Rivera-Calzada A, Famelis N, Llorca O, Geibel S.Type VII secretion systems: structure,functions and transport models[J].Nat Rev Microbiol, 2021, 19(9):567-584 [24]Mietrach N, Damián-Aparicio D, Mielich-Süss B, Lopez D, Geibel S.Substrate Interaction with the EssC Coupling Protein of the Type VIIb Secretion System[J].J Bacteriol, 2020, 202(7):e00646-19 [25]Dreisbach A, Hempel K, Buist G, Hecker M, Becher D, van Dijl JM.Profiling the surfacome of Staphylococcus aureus[J].Proteomics, 2010, 10(17):3082-3096 [26]Kundu M.The role of two-component systems in the physiology of Mycobacterium tuberculosis[J].IUBMB Life 70, 2018, 1(1):710-717 [27]Fortune SM, Jaeger A, Sarracino DA, Chase MR, Sassetti CM, Sherman DR, Bloom BR, Rubin EJ.Mutually dependent secretion of proteins required for mycobacterial virulence[J].Proc Natl Acad Sci U S A, 2005, 102(30):10676-10681 [28]Pang X, Samten B, Cao G, Wang X, Tvinnereim AR, Chen XL, Howard ST.MprAB regulates the espA operon in Mycobacterium tuberculosis and modulates ESX-1 function and host cytokine response[J].J Bacteriol, 2013, 195(1):66-75 [29]Blasco B, Chen JM, Hartkoorn R, Sala C, Uplekar S, Rougemont J, Pojer F, Cole ST.Virulence regulator EspR of Mycobacterium tuberculosis is a nucleoid-associated protein[J].PLoS Pathog, 2012, 8(3):e1002621-e1002621 [30]Bosserman RE, Nguyen TT, Sanchez KG, Chirakos AE, Ferrell MJ, Thompson CR, Champion MM, Abramovitch RB, Champion PA.WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinum[J].Proc Natl Acad Sci U S A, 2017, 114(50):E10772-E10781 [31]Elliott SR, Tischler AD.Phosphate starvation: a novel signal that triggers ESX-5 secretion in Mycobacterium tuberculosis[J].Mol Microbiol, 2016, 100(3):510-526 [32]Jenul C, Horswill AR.Regulation of Staphylococcus aureus virulence[J].Microbiol Spectr, 2018, 7(1):2-2 [33]Lopez MS, Tan IS, Yan D, Kang J, McCreary M, Modrusan Z, Austin CD, Xu M, Brown EJ.Host-derived fatty acids activate type VII secretion in Staphylococcus aureus[J].Proc Natl Acad Sci U S A, 2017, 114(42):11223-11228 [34]Champion PA, Stanley SA, Champion MM, Brown EJ, Cox JS.C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis[J].Science, 2006, 313(5793):1632-1636